week 1

Question 1

major role of platelet

Answer 1

adhesion and aggregation

Question 2

platelets that have
released their contents such as a-granules, ATP and ADP, lysosome granules, which passes through the canalicular system

Answer 2

activated platelets

Question 3

involves your platelet
and your blood vessels.

Answer 3

primary hemostasis

Question 4

involves the
coagulation factors.

Answer 4

secondary hemostasis

Question 5

involves fibrinolysis

Answer 5

tertiary hemostasis

Question 6

Platelets arise from a unique bone marrow cell known as

Answer 6

megakaryocytes

Question 7

1 Mature Megakaryocyte can shed off

Answer 7

2000-4000 of platelets.

Question 8

life span of platelets

Answer 8

8-9 days

Question 9

largest cells in the bone marrow

Answer 9

megakaryocytes

Question 10

Megakaryocytes possess multiple chromosomes copies, also known as

Answer 10

polypoid

Question 11

continuous cell production

Answer 11

hematopoiesis

Question 12

Multiplication of cells

Answer 12

Proliferative Stage

Question 13

From the common myeloid progenitors arises the 3
megakaryocyte lineage committed progenitors

Answer 13

o burst-forming unit (BFU-Meg)
o colony forming unit (CFU-Meg)
o light-density CFU (LD-CFU-Meg)

Question 14

least matured

Answer 14

BFU-Meg

Question 15

intermediate colony

Answer 15

CFU-Meg

Question 16

more mature progenitor

Answer 16

LD-CFU-Meg

Question 17

cloned hundreds of colonies in culture.

Answer 17

BFU-Megs

Question 18

cloned dozens of colonies in culture

Answer 18

CFU-Meg

Question 19

growth factor that will help to stimulate of the
production of the platelets

Answer 19

thrombopoietin

Question 20

least differentiated megakaryocyte

Answer 20

MK-I or megakaryoblast

Question 21

The hallmark is the present of indentation

Answer 21

MK-II or Promegakaryocyte

Question 22

most abundant, easily to recognize, largest
bone cells and they are capable now of shredding
of platelets

Answer 22

MK-III or megakaryocytes

Question 23

a series of membrane lined channel. It will invade from the plasma membrane and it will grow inward to subdivide the entire cytoplasm. It is
identical to megakaryocyte plasma membrane

Answer 23

DMS - demarcation system

Question 24

it has blebs or pseudopods that is used for locomotion

Answer 24

MK-I or megakaryoblast

Question 25

major function are for adhesion

Answer 25

alpha-granules

Question 26

without alpha granules it will result to

Answer 26

gray platelet syndrome

Question 27

primary regulatory factor or cytokine during Megakaryocyte proliferation, differentiation, and platelet production

Answer 27

TPO

Question 28

final stage of maturation that supports thrombopoiesis

Answer 28

megakaryocytes

Question 29

high levels of stress platelets will have a high risk of what disease

Answer 29

cardio vascular diseases

Question 30

no longer look like lymphocytes

Answer 30

megakaryoblasts

Question 31

what are the regulatory factors

Answer 31

- thrombopoietin - interleukin - transcription factors

Question 32

support early stages of megakaryocyte development

Answer 32

IL3, 6, 11

Question 33

early stage cytokine targeting progenitor differentiation

Answer 33

IL-3

Question 34

Late stage cytokine facilitating maturation and platelet release

Answer 34

IL-6

Question 35

Intermediate and late stage cytokine with therapeutic applications

Answer 35

IL-11

Question 36

30% are sequestered by the spleen for

Answer 36

- trauma - inflammation

Question 37

Reference value of platelets

Answer 37

150-400 x 10^9/L

Question 38

Appear in compensation for thrombocytopenia

Answer 38

reticulated platelets or stress platelets

Question 39

The star for the coagulation

Answer 39

platelets

Question 40

MAJOR STRUCTURAL FEATURES OF PLATELET

Answer 40

1. peripheral zone 2. sol gel zone 3. organelle zone 4. membranous zone

Question 41

2 DIVISIONS OF PERIPHERAL ZONE

Answer 41

a. glycocalyx b. plasma membrane

Question 42

Stimulate platelet aggregation

Answer 42

TRACE: T - thrombin R - Ristocetin A - Arachidonic acid C - Collagen E - Epinephrine

Question 43

absorbs albumin, fibrinogen, and other plasma proteins, in many instances transporting them to storage organelles within using a process

Answer 43

endocytosis

Question 44

serves as the physical and chemical barrier between the intracellular and extracellular constituents of the platelets

Answer 44

plasma membrane

Question 45

predominant lipid, it gives us the basic structure of the platelet aside from the microtubules and microfilaments

Answer 45

phospholipid

Question 46

Lies directly beneath the platelet membrane

Answer 46

sol gel zone

Question 47

Composed of protein tubulin which maintains the platelet disc shape

Answer 47

microtubules

Question 48

responsible for contraction

Answer 48

actin and myosin

Question 49

Contain actin and myosin which upon stimulation of the platelet will interact to form actomyosin (thrombosthenin) for clot retraction.

Answer 49

microfilaments

Question 50

The part where the secretory products of platelet come from. * All the contents of the platelets are placed here

Answer 50

Organelle zone

Question 51

how many a-granules are there in each platelet

Answer 51

50-80 granules

Question 52

what is the color of a-granules in osmium dye?

Answer 52

medium gray

Question 53

a-Granules contains

Answer 53

fibrinogen, factor V, von Willebrand factor, platelet factor 4, β thromboglobulin, fibronectin, and albumin

Question 54

how many dense granules are there in each platelet

Answer 54

2-7 granules

Question 55

what is the color of d-granules in osmium dye?

Answer 55

black/opaque

Question 56

important for the activation of coagulation casting

Answer 56

calcium

Question 57

energy source of the platelet to achieve the 8-9 days

Answer 57

ATP - adenosine triphosphate

Question 58

for vasoconstriction which binds endothelial cells and platelet membranes

Answer 58

serotonin

Question 59

dense granules contains

Answer 59

- ATP - ADP - Calcium - Serotonin - Magnesium

Question 60

Lysosomal Granules

Answer 60

Acid phosphatase Hydrolytic enzymes

Question 61

Site of the arachidonic acid metabolism and provides small amounts of calcium to the resting platelet

Answer 61

Dense Tubular System

Question 62

parts of MEMBRANOUS SYSTEM

Answer 62

Dense Tubular System Open Canalicular System

Question 63

“control center” for platelet activation

Answer 63

DTS

Question 64

Important in the storage of ionized calcium

Answer 64

DTS

Question 65

Open to the outside of the platelet

Answer 65

Open Canalicular System