Principle of coagulation Flashcards
involves the interaction
of vasoconstriction,
platelet adhesion and
aggregation and
coagulation enzymes
Hemostasis
Reduction in blood vessel diameter due to
smooth muscle constriction.
Vasoconstriction
Hemostasis
* a complex process that:
- produces a clot to stop the bleeding
- keeps the clot confined
- dissolves the clot as the wound heals
have the thickest wall of the vascular
system
Arteries
are larger and have more irregular
lumen than arteries
Veins
BV is coated into 3 layers
- Tunica Intima
- Tunica media
- Tunica adventitia
The Key Cellular Elements of
Hemostasis
- Vascular intima
- Extravascular tissue factor (TF)
- Platelets.
- Blood Coagulation Factors
- Fibrinolytic proteins
provides the interface
between circulating blood and the body
tissues.
vascular intima
Role of Endothelial Cells
- Immune response
- Vascular permeability
- Proliferation
- Hemostasis
monolayer of metabolically active
endothelial cells
The innermost lining of blood vessels is a
monolayer of metabolically active endothelial
cells
vascular intima
involved in
hemostasis when local vessel is
injured, through swelling and
inflammation
Extravascular Component
The extra-vascular ( tissues
surrounding blood vessels) involved in
hemostasis when local vessel is
injured, through
swelling and
inflammation
vascular
system
consists
of
capillaries,
arteries, and veins.
Responsible for micro circulation
that links between arterial and
venous circulation
Capillaries
Microscopic continuation of
arteries giving off meta arterioles joining
capillaries
Arterioles
microscopic size of veins connecting to
capillaries
Venules
Thinnest walled and most numerous of
blood vessels compose of basement
membrane that is tightly anchored with
collagen that offers support for
microvascular unit.
Capillaries
Blood normally carried within vessels whose
physical capabilities include Contraction
(narrowing) and Dilation, which are controlled by
the smooth muscle of the vessel media.
Role of Blood Vessels in Hemostasis
Is the process where by on vessel
injury, Plasma protein, Tissue factors
and Calcium interact on the
surface of the platelets to form a
Fibrin clot.
Coagulation
provide a surface for the
coagulation
reaction,
and
interact
with
fibrin to form
a stable
platelet
fibrin
clot
Platelets
major role of the
hemostatic system
maintain a complete
balance of the body’s
tendency toward clotting
and bleeding
Concept of
HYPOCOAGULATION
- poor clot formation
- excessive fibrinolysis
- hypocoaguable dse
There
are certain
conditions
associated
with excessive
bleeding
are referred
to
as
Hypo-coagulable states.
