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Secondary Hemostasis Flashcards

1
Q

Example of zymogen

A

Factor II, VII, IX, X, XI, XII, PREKALLIKREIN

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2
Q

Involves the enzymatic activation of series of plasma proteins in the coagulation system to form fibrin meshwork

A

Secondary hemostasis

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3
Q

Example of contact factor

A

Factor XII, HMWK, PREKALLIKREIN, KALLIKREIN,

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4
Q

All cofactors synthesized in the liver except

A

Prekal, HMWK, calcium, and tissue factor

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5
Q

Synonym for tissue factor

A

Thromboplastin or tissue thromboplastin

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6
Q

Synonym of factor V

A
  • labile factor
  • preaccelerin
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7
Q

Synonym for factor VII

A
  • stable factor
  • proconvertin
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8
Q

Synonym for factor VIII

A
  • antihemophilic factor
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9
Q

Synonym for factor IX

A
  • Christmas factor
  • plasma thromboplastin component
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10
Q

Synonym for factor X

A

Stuart Prower factor

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11
Q

Synonym for factor XI

A

Plasma thromboplastin antecedent

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12
Q

Synonym for factor XII

A

Hageman factor
Glass factor
Contact factor

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13
Q

Synonym for factor XIII

A

Fibrin stabilizing factor
Laki-Lorand factor
Fibrinase

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14
Q

Other name of prekallikrein

A

Fletcher factor

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15
Q

factor to initiate in the Intrinsic Pathway

A

factor XII

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16
Q

Other name of high molecular weight kininogen

A
  • Fitzgerald factor
  • Williams factor
  • Flaujeac factor
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17
Q

What is substrate

A

Will act upon enzyme

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18
Q

What is cofactors

A

Aids or assists to activate a coagulation factor

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19
Q

Classification of coagulation factor by hemostatic function

A

Substrate
Cofactor
Enzyme

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20
Q

Hemostatic function of substrate, cofactors, enzymes

A

Substrate - fibrinogen (factor I)
Cofactor - factor V and factor VIII:C
Enzymes - serine proteases (Ia, Xa, XIa), transaminase, factor XIIIa, prekallikrein

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21
Q

Classification of coagulation factors by physical properties

A

Contact group
Prothrombin group (vit k dependent group)
Fibrinogen group

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22
Q

Physical properties of contact group, prothrombin group, fibrinogen group

A

Contact group - XII, XI, prekal, HMWK
Prothrombin group - X, IX, VII, II
fibrinogen group - I, V, VIII, XIII

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23
Q

If you have deficiency in factor _____, there will be no bleeding

A

Factor XI

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24
Q

This protein stabilizes the
linkage between the fibrin
monomers of the blood clot.

A

factor XIII

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25
What activates factor XIII
Thrombin
26
Deteriorates upon storage
Factor V and VIII
27
Fibrinogen is increased in what condition
Pregnancy Inflammation Use of contraceptive
28
Act as substrate to plasmin
Fibrinogen
29
Ref range of fibrinogen
200-400 g/dl
30
No fibrinogen
Afibrinogenemia
31
Non functional fibrinogen
Dysfinrinogenemia
32
<200 g/dl fibrinogen or low level fibrinogen
Hypofibrinogenemia
33
Half life of factor XI
48-84 hours
34
Half life of factor XIII
150 hours
35
What activates common pathway
Factor IXa and VIIa
36
Half life of factor XII
48-70 hrs
37
What activates factor XII
Activated by collagen contact (negatively charge surface) and kallikrein
38
A stable globulin that is not consumed
Factor XII
39
What activates factor XI
activated factor XII or F XIIa
40
factor XI activates what factor?
factor XI complexes with calcium to activates factor IX
41
Serine protease that is not consumed in clotting process
Factor X
42
Serine protease beta or gamma globulin that is partly consumed in clotting found in serum or plasma
Factor XI
43
factor IX activates what factor?
Factor IX that complexes with calcium, VIIIa and phospholipid activates Factor X
44
half life of factor X
48 hrs to 52 hrs
45
Serine protease not consumed in the clotting process found in both serum and plasma
factor X
46
half life of factor IX
24 hours
47
who activates factor VIII
thrombin
48
fastest pathway
Extrinsic pathway
49
half life of factor VII
6 hours
50
shortest half life
factor VII
51
longest half life
factor XIII and factor I
52
what activates factor VII
tissue factor that complexes with calcium activates factor VII
53
factor V is unstable when stored in
citrated plasma
54
half life of factor V
24 hours
55
who activates prothrombin or factor IIa
activated factor V complexes with calcium and phospholipid to activated prothrombin to form thrombin
56
Half-life insoluble used to designate the clot accelerating action of extract of tissue
factor III
57
half life of factor II
60 hours
58
The substrate for thrombin and precursor of fibrin
factor I or fibrinogen
59
It is partially adsorbed by barium sulfate but not adsorbed by aluminium hydroxide
prekallikrein
60
half life of prekallikrein
35 hours
61
dissolution of fibrin
factor XII
62
do not cause clinical bleeding disorders
Deficiencies of Factor XII, HMWK, or prekallikrein
63
Activation occurs when a vessel is injured, exposing the subendothelial basement membrane and collagen
intrinsic pathway
64
ACTIONS OF THROMBIN
1 Converts fibrinogen to fibrin 2 Activates Factor XIII 3 Enhances the activity of Factors V & VIII:C 4 Induces platelet aggregation
65
THROMBIN-MEDIATED REACTIONS IN HEMOSTASIS
procoagulant coagulation inhibitor tissue repair
66
Induces platelet activation and aggregation
procoagulant
67
Induces cellular chemotaxis
tissue repair
68
positive chemotaxis
toward injury
69
negative chemotaxis
away stimulates
70
To maintain balance to avoid thrombosis/bleeding.
INHIBITORS OF COAGULATION (ANTICOAGULANTS)
71
Glycoprotein that is produced by the liver and is a major inhibitor of blood coagulation.
protein C
72
Inhibits thrombin and inactivates the clotting cascade.
thrombomodulin
73
Major inhibitor of Thrombin and Factor Xa
antithrombin II
74
Forms complex with thrombin, kallikrein, thus inhibiting their activities
alpha 2 macroglobulin
75
inhibits VIIa which is a tissue complex factor.
Lipoprotein associated inhibitor (LACI)
76
Inactivates Factor XIIa and plasma kallikrein, Factor XIa and plasmin.
C1 inhibitor
77
A slow reacting thrombin inhibitor which inhibits Factor XIa and Xa
alpha 1 antitrypsin
78
79

hema312 (8 decks)

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