Week 08 - The nucleoside Phosphate reactions

Question 1

Adenylate Kinase reaction prevents ATP ____

Answer 1

building up

Question 2

Adenylate Kinase reaction generates

Answer 2

ATP

Question 3

Is Adenylate Deaminase reaction reversible?

Answer 3

No

Question 4

Adenylate Deaminase is especially important in…

Answer 4

Important in skeletal muscle fibres (type 2 . fast twitch)

Question 5

Adenylate Deaminase NH2 (amino group) from adenine forming _____ ______

Answer 5

inosine monophosphate (IMP)

Question 6

Adenylate Kinase & Adenylate deaminase are only important when …

Answer 6

muscles are involved in intense exercise (type 2 fibres)

Question 7

Role of ammonia…

Answer 7

preventing metabolic acidosis (stops muscle form becoming too acidic)

Question 8

High [La] in muscle would indicate…?

Answer 8

Anaerobic glycolysis has been working as the energy production

Question 9

Glycogen synthesis occurs mostly in _____ and ____

Answer 9

hepatocytes and muscle cells

Question 10

4 steps of glycogen synthesis

Answer 10

1. glucose phosphorylated upon entering cell
2. Phosphoglucomutase reactions
3. UDP (glucose pyrophosphorylase)
4. Glycogen synthase
   4B. Branching enzyme

Question 11

Glycogen synthase is a ____ enzyme and is _____versible

Answer 11

leading enzyme, irreversible

Question 12

Glycogenolysis

Answer 12

Glycogen broken down into glucose

Question 13

Gluconeogenesis

Answer 13

Synthesis of glucose from non CHO

Question 14

Gluconeogenesis from pyruvate: 3 enzymes that are reversible

Answer 14

1. Hexokinase
2. Phosphofructokinase
3. Pyruvate kinase

Question 15

Gluconeogenesis from pyruvate uses___ energy that u get from glycolysis

Answer 15

3 x

Question 16

does Gluconeogenesis from pyruvate occur in muscle, why or why not?

Answer 16

No. Muscle does not have glucose-6-phosphatase

Question 17

Glucogenesis from glycerol steps

Answer 17

1. Glycerol kinase (mainly liver)

2. Glycerol phosphate dehydrogenase reaction

Question 18

Triacylglycerol synthesis needs (2)

Answer 18

activated glycerol & activated Fatty acids

Question 19

FFAs we must get from our diet

Answer 19

• Linoleic acid (an omega-3- fatty acid)
• Alpha linolenic acid (an omega-6-fatty acid
• gamma linoleic acid (an omega-6-fatty acid)
• lauric acid ( a saturated fatty acid)
• Palmitoleic acid (a monounsaturated fat)

Question 20

Fatty Acid Synthase has 3 active sites..?

Answer 20

• Ketoreductase (KR)
• Dehydratase (DH)
• Enol reductase (ER)