Week 06 - Anaerobic Glycolysis Flashcards
Anaerobic Glycolysis is completely _______ dependent
Carbohydrate
Anaerobic glycolysis uses _______ & ______ as fuel (to produce ATP)
Glucose (blood and cell) & Glycogen (cell only)
The product of glycolysis is …
pyruvate
Pyruvate can be converted into ______ or used for ____ ______ production
converted into lactate or used for aerobic energy production.
when lactate is the product or pyruvate, it is called _____ ______
Anaerobic Glycolysis
Where does the process of anaerobic glycolysis occur?
In the cytosol of the cell
What is Substrate Level Phosphorylation ?
Production of ATP via anaerobic glycolysis
Does anaerobic Glycolysis used O2?
No. Does not require O2
Anaerobic glycolysis has _____ power but ____ capacity
HIGH power, LOWER capacity. (80 seconds all out activity)
______ ions create fatigue & pain
Hydrogen ion
How efficient is anaerobic glycolysis ?
Not very efficient - about 8% of energy in bonds is converted to ATP
Name two fates of lactate
- Leave cell -> blood -> liver -> gluconeogenesis (make glucose)
- Remain in cell -> pyruvate -> TCA -> Energy converted to glycogen -> glyconeogenesis (make glycogen)
Glucose -> pyruvate -> lactate (in cytosol): Name the system
Anaerobic Glycolysis
Glucose -> pyruvate -> into mitochondria for oxidation
Aerobic Glycolysis
Which reaction is Glucose -> Glucose - 6 -P? Is it reversible and how many ATPs used?
- Hexokinase. Irreversible. 1 ATP used.
Which reaction is glucose - 6 - phosphate fructose - 6 - phosphate?
- glucose phosphate isomerase
Is Glucose phosphate isomerase reversible?
Yes
Glucose phosphate isomerase converts _____ into ______
glucose into fructose
Which reaction is Fructose - 6 - phosphate -> fructose -1, 6- bisphosphate?
- Phosphofructokinase (PFK)
Is Phosphofructokinase (PFK) reversible?
No
_________ controls the overall rate of glycolysis (flux of glycolysis)
Phosphofructokinase (PFK)
Which reaction is Fructose –1,6 – bisphosphate ↔ glyceraldehyde–3–phosphate + dihydroxy acetone–phosphate?
- Aldolase
Aldolase converts ____ to _____
6 - Carbon molecule into 2 Carbon molecules.
is Aldolase reversible?
Yes
Which reaction is Dihydroxyacetone phosphate ↔ glyceraldehyde–3–phosphate ??
- Triosephosphate isomerase
is Triosephosphate isomerase reversible?
Yes
Which reaction is Glyceraldehyde–3–phosphate ↔ 1,3 bisphosphoglycerate?
- Glyceraldehyde phosphate dehydrogenase
is Glyceraldehyde phosphate dehydrogenase reversible?
Yes
Which reaction is 1,3 bisphosphoglycerate ↔ 3-phosphoglycerate??
- Phosphoglycerate kinase
Is Phosphoglycerate kinase reversible?
Yes
Is Phosphoglycerate kinase oxidative phosphorylation?
No. it is Substrate level phosphorylation
Which reaction is 3 – phosphoglycerate↔ 2 – phosphoglycerate?
- Phosphoglycerate mutase
Is Phosphoglycerate mutase reversible?
Yes
In Phosphoglycerate mutase the Carbon number ____ is moved to Carbon number _____
3 C to 2 C
Which reaction is 2 – phosphoglycerate ↔ Phosphenol pyruvate + H2O
- Enolase
Is Enolase reversible?
Yes
Enolase removes _____
H2O
Which reaction is Phosphoenol pyruvate → Pyruvate
- Pyruvate Kinase
Is Pyruvate Kinase reversible?
No
Is Pyruvate Kinase Substrate level phospohrylation? (in cytosol)
Yes
Which reaction Pyruvate Lactate
- Lactate dehydrogenase (LDH)
- Reversible
Name 3 fates iof pyruvate
- Lactate (Cytosol - Anaerobic glycolysis)
- Pyruvate to TCA cycle (Mitochondria - aerobic)
- Alanine (AA) - occurs in ex’s
