WBC Variants Flashcards
Toxic Granulation
Dark purple-blue granules in PMNs and Bands.
Often seen with toxic vacuoles, Dohle bodies and a shift to the left.
Toxic Granulation Cause
Stimulation of granulocytic cells results in fewer mitotic divisions. Prevents normal dilution of nonspecific granules.
Often seen with toxic granules, Dohle bodies and a shift to the left.
Toxic Vacuoles
Clear holes contained in the cytoplasm of phagocytic cells
Toxic Vacuoles Cause
Severe bacterial infection or toxic states
Identify
Toxic Vacuoles
Identify
Toxic Granules
Hypersegmentation
Segmented neutrophils with six or more nuclear lobes
Cells often larger than normal
hypersegmentation Cause
Congenital or Megaloblastic change
Identify
Hypersegmentation
Pelger-Huet Anomaly
Benign congenital hyposegmentation of PMNs
No granulocytes with > 2 nuclear lobes
Pince-nez and Stodtmeister cells
Increased bands
Pseudo Pelger-Huet will have some normal PMNs present
Identify
Pelger-Huet Anomaly
Reactive Lymph
Activated T-Lymphocyte
Identify
Reactive Lymph
Identify
Pelger Huet Anomaly
Identify
Plasma Cell and Reactive Lymph
Barr Body
Represent an extra X-Chromosome unnecessary for normal nuclear function
Expressed as a miniature lobe or “drumstick” protruding from the nucleus of PMNs
Normal in females. In males that are XXY or XXXY
Not Reported
Identify
Barr Body
Plasmacytoid Lymph
Activate B-Lymph
Slightly larger with darker royal blue cytoplasm and heavily clumped chromatin
Lacks very eccentric nucleus and well developed golgi of plasma cell
Identify
Plasmacytoid
Pyknotic Degeneration(necrobiotic)
Cell undergoing Apaptosis or programed cell death.
One or more dense masses.
Not nrbcs!!
Identify
Pyknotic Cell
Identify
Pyknotic Cell
Smudge Cells
Cells destroyed by making peripheral smear.
Associated with increased cell fragility.
Often seen in CLL and ALL
Can add albumin and remake slide to avoid creating this artifact.
Identify
Smudge Cell
Septicemia
Bacteria in Blood
Reported!!
Identify
Septicemia
Identify
Septicemia
