Myelocytic Series Flashcards
Myelocytic Series
Granulocytic Series
Myeloblast
-Cell size: 12-20 um
-N/C ratio 4:1
-Round-oval nucleus,
“rounded refrigerator corners” *
-Central or eccentric nucleus
-Light red-purple fine meshwork chromatin with no aggregation of material
-1-5 nucleoli*
-Scanty basophilic cytoplasm
-No granules
-May contain Auer rods
Identify
Myeloblast
Identify
Myeloblast
Promyelocyte
-Cell size: 15-23 um
-N/C ratio 3:1
-Round-oval nucleus,
-Central or eccentric nucleus
-Light red-purple fine meshwork c-chromatin, possibly slight aggregation at nuclear membrane
-1-3 nucleoli
-Basophilic cytoplasm (may be slightly increased over blast)
-Coarse azurophilic nonspecific (primary) granules*
Identify
Promyelocyte
Identify
Myelocyte
-Cell size: 10-18 um
-N/C ratio 2:1 or 1:1
-More round-oval nucleus*
-Central or eccentric nucleus
-Red-purple fine chromatin with slightly aggregated pattern*
-May or may not have nucleoli
-Moderate bluish - pink
cytoplasm
-nonspecific (primary) and
specific (secondary) granules*
Identify
Myelocyte
Identify
Myelocyte
Metamyelocyte
-Cell size: 10-18 um
-N/C ratio 1:1
-Indented (kidney shaped) nucleus*
-Central or eccentric nucleus
-Light blue-purple with chromatin c-clumps easily distinguishable
-No nucleoli
-Moderate bluish - pink cytoplasm
(occasionally clear pink)
-Specific (secondary) granules
(few non-specific)
Identify
Metamyelocyte
Identify
Metamyelocyte and PMN
Band Neutrophil
-Cell size: 10-16 um
-N/C ratio 1:1
-Elongated narrow band shape of uniform thickness, singular lobe*
-Central or eccentric nucleus
-Deep blue-purple coarsely
granular nuclear chromatin
(distinct parachromatin)
-No nucleoli
-Abundant pink cytoplasm
-Fine violet-pink specific granules
Identify
Band Neutrophil
Polymorphonuclear Segmented Neutrophil
Cell size: 10-16 um
N/C ratio 1:1
2-5 distinct nuclear lobes
(filament connecting lobes) *
Central or eccentric nucleus
Deep blue-purple coarsely
granular nuclear chromatin
(distinct parachromatin)
No nucleoli
Abundant pink cytoplasm
Fine violet-pink specific granules
Identify
Polymorphonuclear Segmented neutrophil
Eosinophil
Red Granulated Cell
Basophil
Basophil
Leukomoid Reaction
-Transient, reactive condition characterized by moderate to severe increased WBC and a
Shift to the Left
(increased immature granulocytes in blood)
*Infection
*Physiological leukocytosis
WBC Malignancies
Malignant (cancerous) condition often characterized by moderate to severe increased WBC
These general malignant conditions may have a
* Shift to the Left (immature granulocytes in the peripheral blood) depending on the specific disease process…
*Leukemias
*Myelodysplastic Syndromes
