WBC: reactive & non-neoplastic disorders of leukocytes

Question 1

inc production of granulocytes occur in response to 2 types of infection. what are they & the difference:

Answer 1

• localised bacterial infection: contained by neutrophil = steady state granulopoeisis
• Systemic: neutrophils consumed = fail to contain infection locally = emergency granulocytopoeisis

Question 2

characteristic of Pelger-Huët anomaly

Answer 2

• hyposegmented nucleus

- lack toxic granulation/Döhle bodies

Question 3

characteristic of Chediak-higashi granules

Answer 3

• grey atypical granules in neutrophil

Question 4

characteristic of May hegglin anomaly

Answer 4

• giant plts
• Thrombocytopenia
• Neutrophil cytoplasmic inclusions (like Döhle body)

Question 5

Dohle bodies are _ and reflect _ _

Answer 5

a) Aggregates of RNA = dakr blue in cytoplasm

b) cellular immaturity

Question 6

Toxic granulation are _ and reflect _ _

Answer 6

a) prominent basophilic cytoplasmic granules

b) cellular immaturity

Question 7

MOrphology changes associated w/ reactive lymphocytosis (6)

Answer 7

• Inc size
• Inc cytoplasm
• Inc basophilic cytoplasm
• Irreg. shaped nucleus
• Indented shaped nucleaus
• Indented/cleaved nucleus
• Plasmacytoid appearance