Intro to lymphoid neoplasia Flashcards
1
Q
classifications of lymphoid neoplasms
A
• subcategory of myeloid neoplasm & acute leukaemia
- B-lymphoblastic leaukaemia/lymphoma
- T-lymphoblastic leukaemia/lymphoma
2
Q
What investigations would you undertake for lymphoblastic leukemia/lymphoma
A
(same as AML)
- Morphology in blood & BM
- cytochemistry
- *Immunophenotyping analysis
- *Cytogenic & genetic analysis
3
Q
dx this? further test
- anaemia
- thrombocytopenia
- neutropenia, eosinophilia, basophilia
- varied blast morphology
A
dx: ALL (acute lymphoid leukaemia)
further test:
- cytochemical stains = neg
- immunophenotyping = CD45, CD34, TdT
4
Q
dx this? further test
- small & monomorphic blast (80%)
- large & pleomorphic blast (20%)
A
dx: B-cell lymphoblastic leukaemia/lymphoma (B-ALL)
test:
- immunophenotype
- cytogenetics
5
Q
dx this? further test
- leukocytosis
- blast
A
dx: T-cell acute lymphoblastic leukaemia/lymphoma
Test
- immunophenotype; CD3+
- cytochemistry: +ve for acid phosphatase
- cytogenetics`
6
Q
define richter syndrome
A
CLL transforms to higher grade neoplasm like acute leukaemia
7
Q
dx this? further testing?
- splenomegaly
- WBC >100 x10^9/L
- Prolymphocytes >55%
A
dx B-cell prolymphocytic leukaemia (B-PLL)
further test:
- cytogenetics
- immunophenotype
8
Q
pathopysiology of T-cell prolymphocytic leukaemia (T-PLL)
A
- commonly in elderly males
- lymphocytosis
- anaemia, thrombocytopenia
- cytogenetics on 14q11
