WBC morphology & function Flashcards
Name the cell types
Name the cell type
Name the cell type
Name the cell types
In what species are lymphocytes not smaller than neutrophils?
bovines
Name the cell type
monocyte
Name the cell type & species.
Eosinophil, bovine- small, densely packed granules
Name the cell type & species.
eosinophil: canine- variable appearance
Name the cell type & species.
eosinophil: feline- rod shaped granules
Name the cell type & species.
eosinophil: equine- dense large granules
label the cell type and species.
What are the blood pools for neutrophils?
circulating, marginating, tissues
which species responds more readily to tissue demands for neutrophils
Canine
What is the ratio circulating pool: marginating pool in most species and then in felines?
most species: 50:50
felines: 30:70
What conditions/disease could alter the distribution of neutrophils across the different pools?
inflammation
stress
excitement
endotoxemia
What dictates time of neutrophils in circulation?
tissue demand for neutrophils
When is the time of neutrophils in circulation shortened?
inflammation
Describe the distribution of lymphocytes in the body?
What structure transports lymphocytes from l.n. back to circulation?
thoracic duct
What is the half-life of monocytes in blood? in tissues?
blood: 12hrs-3days
tissues: weeks-months
What inflammatory mediator is important for eosniphil chemoattraction and production?
IL-5
What cell is abnormal to observe in the blood?
mast cell
What cytopenias are clinically important?
neutropenia
lymphopenia
eosinopenia
Clinically important increases?
neutrophilia
eosinophilia
basophilia
monocytosis
lymphocytosis
What does neutrophilia in combination with left-shift indicate?
severe inflammation
consumption of neutrophils
Describe the cell.
left shifted neutrophil
What stages of neutrophil development involve mitosis? maturation and storage?
mitosis: myeloblast-promyelo-myelocyte
maturation &storage: meta-band-neutrophil
What are some causes of left-shifting in neutrophils?
inflammation: infectious & non-infectious
hereditary (Pelger Huet)
neoplasia (CML, AML)
What does the blood film indicate?
neutrophil left-shift
What is the term used to describe this condition?
leukemia
On a blood film, a neutrophilia w/ left shift is observed with mature neutrophils predominating. What type of left-shift is this?
regenerative left shift
On a blood film, a neutropenia/normal neutrophil counts is observed with immature neutrophils predominating. What type of left shift is this?
degenerative left shift
