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Clinical Pathology > WBC morphology & function > Flashcards

WBC morphology & function Flashcards

1
Q

Name the cell types

A
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2
Q

Name the cell type

A
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3
Q

Name the cell type

A
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4
Q

Name the cell types

A
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5
Q

In what species are lymphocytes not smaller than neutrophils?

A

bovines

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6
Q

Name the cell type

A

monocyte

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7
Q

Name the cell type & species.

A

Eosinophil, bovine- small, densely packed granules

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8
Q

Name the cell type & species.

A

eosinophil: canine- variable appearance

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9
Q

Name the cell type & species.

A

eosinophil: feline- rod shaped granules

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10
Q

Name the cell type & species.

A

eosinophil: equine- dense large granules

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11
Q

label the cell type and species.

A
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12
Q

What are the blood pools for neutrophils?

A

circulating, marginating, tissues

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13
Q

which species responds more readily to tissue demands for neutrophils

A

Canine

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14
Q

What is the ratio circulating pool: marginating pool in most species and then in felines?

A

most species: 50:50

felines: 30:70

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15
Q

What conditions/disease could alter the distribution of neutrophils across the different pools?

A

inflammation

stress

excitement

endotoxemia

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16
Q

What dictates time of neutrophils in circulation?

A

tissue demand for neutrophils

17
Q

When is the time of neutrophils in circulation shortened?

A

inflammation

18
Q

Describe the distribution of lymphocytes in the body?

A
19
Q

What structure transports lymphocytes from l.n. back to circulation?

A

thoracic duct

20
Q

What is the half-life of monocytes in blood? in tissues?

A

blood: 12hrs-3days
tissues: weeks-months

21
Q

What inflammatory mediator is important for eosniphil chemoattraction and production?

A

IL-5

22
Q

What cell is abnormal to observe in the blood?

A

mast cell

23
Q

What cytopenias are clinically important?

A

neutropenia

lymphopenia

eosinopenia

24
Q

Clinically important increases?

A

neutrophilia

eosinophilia

basophilia

monocytosis

lymphocytosis

25
Q

What does neutrophilia in combination with left-shift indicate?

A

severe inflammation

consumption of neutrophils

26
Q

Describe the cell.

A

left shifted neutrophil

27
Q

What stages of neutrophil development involve mitosis? maturation and storage?

A

mitosis: myeloblast-promyelo-myelocyte

maturation &storage: meta-band-neutrophil

28
Q

What are some causes of left-shifting in neutrophils?

A

inflammation: infectious & non-infectious

hereditary (Pelger Huet)

neoplasia (CML, AML)

29
Q

What does the blood film indicate?

A

neutrophil left-shift

30
Q

What is the term used to describe this condition?

A

leukemia

31
Q

On a blood film, a neutrophilia w/ left shift is observed with mature neutrophils predominating. What type of left-shift is this?

A

regenerative left shift

32
Q

On a blood film, a neutropenia/normal neutrophil counts is observed with immature neutrophils predominating. What type of left shift is this?

A

degenerative left shift

Clinical Pathology (6 decks)

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