WBC - Chapter 28 Abnormalities

Question 1

What are quantitative abnormalities?

Answer 1

numbers in PB, BM, or both

Question 2

What is leukopenia?

Answer 2

Decrease in cells (neutropenia)

Question 3

What is leukocytosis?

Answer 3

Increase in cells (reactive lymphocytosis)

Question 4

What are qualitative abnormalities?

Answer 4

defect in cell component

Question 5

What are types of defects can be found in qualitative abnormalities?

Answer 5

morphological
functional
combined

Question 6

What are morphological defects?

Answer 6

primarily a structural abnormality (Pelger-Huet)

Question 7

What are functional defects?

Answer 7

defect in the way a cell functions

Question 8

What are combined defects?

Answer 8

disorders that involve structural and metabolic changes

Question 9

What is hereditary etiology?

Answer 9

genetically passed allele

Question 10

What is recessive etiology?

Answer 10

homozygous and hemizygous conditions (chediak-higashi syndrome

Question 11

What is dominant etiology?

Answer 11

heterozygous as well as homozygous conditions

Question 12

What is acquired etiology?

Answer 12

occurs in individual but not genome

Question 13

What is congenital etiology?

Answer 13

present at birth
developmental abnormalities
(genetic component not yet IDed)

Question 14

What is postnatal etiology?

Answer 14

acquired during childhood or adult
environmental - drug induced
secondary - in response to cancer

Question 15

What is idiopathic etiology?

Answer 15

unknown cause

“the path of idiots”

Question 16

What is acute?

Answer 16

rapid onset of symptoms

rate of disease progression

Question 17

What is chronic?

Answer 17

gradual onset

Question 18

What are the cell lineages?

Answer 18

Granulocytes
Monocytes
Lymphocytes
Histiocytes
Multiple