H1T3 Review Flashcards
The process whereby blood is ready and able to become a solid in a needed area; and remain flowing as a liquid elsewhere is
hemostasis
The function of factor XIII is
stabilize fibrin monomers
A patient presents with deep bleeding and possible hemerthroses. There is no evidence of a wound. What is likely responsible?
Primary hemostasis
Which factors are involved in activating the intrinsic system and require contact with a negatively charged surface for their activation?
Factors XII, XI, kallikrein, HMWK
The average life span of a platelet in the peripheral blood is approximately _____ days.
10
The soluble pieces formed during fibrinolysis are called _____.
fibrin split products
As part of clot initiation, platelets release _____.
All of these
Platelet production is regulated by _____.
Thrombopoietin
The average platelet count ranges from _____ of whole blood.
150 - 400 x 10^3/uL
A patient is placed on heparin therapy. The dosage is monitored using the following test:
Partial thromboplastin time
A patient is placed on Plavix therapy. The dosage is monitored using the following test:
none of these
In the extrinsic pathway, what is NOT a part of the activation of factor X
HMWK
Which coagulation factor can activate plasminogen?
XII
What is factor I?
Fibrinogen
What is factor II?
Prothrombin
What is factor IV?
Ionic calcium
What is factor VIII?
antihemophilic factor
What is factor IX?
Christmas factor
What is factor XII?
Hageman factor
What is factor XIII?
Fibrin stabilizing factor
Platelets begin to be separated by _____ within the megakaryocyte.
Demarcation membrane system
The “cascade” theories state that most of the activated coagulation factors function as:
enzymes
Thrombocytosis is classified as:
Platelet count more than 500 x 10^3/uL
A patient presents with purpura and epistaxis. Which of the following tests might be abnormal?
Platelets
Following repair of the tissue, when the clot is no longer needed it is removed by
Fibrinolysis
Each of the following is involved in hemostasis except
regulation of blood pressure
What is it called when platelets bind to the blood vessel surface?
Platelet adhesion
Which describes the events involved in secondary hemostasis?
lead to the formation of a chemically stable fibrin clot
What is NOT a function of platelets.
Carry nutrients
The antihemophilic factor is
VIII
What activates the intrinsic pathway?
Exposure to negatively charged surfaces
Approximately what portion of the platelets released into the circulating bloodstream are sequestered in the spleen
1/3
What bone marrow cell is the precursor of platelets?
Megakaryocyte
The process of breaking down a clot is called
Fibrinolysis
The proteolytic enzyme that is responsible for fibrinolysis
Plasmin
