WBC - BOC flashcards
1
Q
An increased amount of cytoplasmic basophilia in a blood cell indicates _____.
A
B decreased cytoplasmic maturation
2
Q
The term “shift to the left” refers to:
A
Immature cell forms in the perpheral blood
3
Q
A term that means varying degrees of leukocytosis with a shift to the left and occasional nucleated red cells in the peripheral blood is:
A
Leukoerythroblastosis
4
Q
Cells that produce antibodies and lymphokines are
A
Lymphocytes
5
Q
The peripheral blood monocyte is an intermediate stage in the formation of the
A
Fibroblast
6
Q
Specific (secondary) granules of the neutrophilic granulocyte
A
appear first at the myelocyte stage
7
Q
In normal adult bone marrow, the most common granulocyte is the
A
metamyelocyte
8
Q
Elevation of the total granulocyte count above 7.7x10^3 is termed
A
absolute neutrophilic leukocytosis
9
Q
Elevation of the total white cell count above 12x10^3 is termed
A
Leukocytosis
10
Q
Elevation of the granulocyte percentage above 75% is termed:
A
relative neutrophilic leukocytosis
11
Q
Elevation of the lymphocyte percentage above 47% is termed
A
relative lymphcytosis
12
Q
Terminal deoxynucleotidyl transferase (TdT) is a marker found on:
A
lymphblasts
13
Q
Multipotent stem cells are capable of producing
A
lymphoid and myeloid stem cells
14
Q
The philadelphia chromosome is formed by a translocation between the:
A
long arm of chromosome 22 and long arm of chromosome 9
15
Q
Phagocytosis is a function of
A
granulocytes
16
Q
The white cell feature most characteristic of pernicious anemia is
A
Hypersegmentation
17
Q
Which of the following conditions is not associated with a high incidence of leukemia
A
Megaloblastic anemia
18
Q
The M:E ratio in chronic myelocytic leukemia is usually
A
high
19
Q
In the FAB classification, myelomonocytic leukemia would be
A
M4
20
Q
Abnormalities found in erythroleukemia include
A
megaloblastoid development
21
Q
Neutropenia is not usually associated with
A
Hodgkin disease
22
Q
Auer rods are most likely present in which of the following?
A
Acute myelocytic leukemia
23
Q
The following results were obtained on a 45 year old man with chills. High WBC, philadelphia neg, toxic gran, dohle bodies and vacuoles
A
Neutrophilic leukemoid reaction
24
Q
In an uncomplicated case of infectious mononucleosis, which of the following cells are affected?
A
Lymphocytes
25
The atypical lymphocyte seen in the peripheral smear of patients with infections mono is probably derived from which of the following?
B lymphocytes
26
The disease most frequently present in patients with atypical lymphocytosis and persistently negative tests is
CMV infection
27
Dwarf or micro megakaryocytes may be found in the peripheral blood of patients with
myelofibrosis with myeloid metaplasia
28
Which of the following is associated with pseudo-Pelger Huet anomaly?
Myelogenous leukemia
29
Auer bodies are:
predominately found in acute myelogenous leukemia
30
The absence of the philadelphia chromosome in granulocytic leukemia suggests
rapid progression of the disease
31
Increased numbers of basophils are often seen in
chronic myelocytic leukemia
32
A hypercellular marrow with an M:E ratio of 6:1 is most commonly due to:
granulocytic hyperplasia
33
Which is the most predominant form of secondary hematologic malignancy seen in patients with multiple myeloma
Acute myelomonocytic leukemia
34
In chronic myelocytic leukemia, blood histamine concentrations tend to reflect the
number of basophils present
35
Biochemical abnormalities characteristic of polycythemia vera include
increased serum B12 binding capacity
36
Auer rods:
are lysosome and acid phosphatase positive
37
50-90% myeloblasts in aperipheral blood is typical of which of the following?
acute myelocytic leukemia
38
The M:E ratio in acute myelocytic leukemia is usually
high
39
which of the following is most closely associated with acute promyelocytic leukemia?
disseminated intravascular coagulation
40
which of the following is most closely associated with chronic myelomonocytic leukemia?
lysozymuria
41
The absence of intermediate maturing cells between the blast and mature neutrophil commonly seen in acute myelocytic leukemia and myelodysplastic syndromes is called
leukemic hiatus
42
Which of the following is most closely associated with chronic myelogenous leukemia?
Philadelhia chromosome
43
The bone marrow in the terminal stage of erythroleukemia is often indistinguishable from that seen in
acute myelocytic leukemia
44
A block in the differentiation or maturation of, and an accretion of immature hematopoietic progenitors is a hallmark of:
acute myelogenous leukemia
45
all stages of neutrophils are most likely to be seen in the peripheral blood of a patient with
chronic myelocytic leukemia
46
All of the following conditions are myeloproliferative disorders except
Lymphocytic leukemia
47
A patient has a tumor that concentrates erythropoietin. He is most likely to have which of the following types of polycythemia?
polycythemia associated with renal disease
48
Which of the following types of polycythemia is most often associated with emphysema?
polycythemia, secondary to hypoxia
49
Hemorrhage in polycythemia vera is the result of
abnormal platelet function
50
A patient diagnosed with polycythemia vera 5 years ago now has a normal HCT, decreased Hg and microcytic, hypochromic red cells. What is the most probable cause for the current blood situation?
phlebotomy
51
A patient has been treated for polycythemia vera for several years. His blood smear now shows oval macros, HJ bodies, hyper segs, large platelets. The most probable cause of this blood picture is
Chemotherapy
52
In infectious mononucleosis, lymphocytes tend to be:
enlarged and indented by surrounding structures
53
In comparison to malignant lymphoma cells, reactive lymphocytes
are morphologically more variable throughout the smear
54
T-cell acute lymphocytic leukemia (ALL) is closely related to:
lymphoblastic lymphoma
55
In the FAB classification, ALL is divided into groups according to
morphology
56
increased levels of TdT activity are indicative of
acute lymphocytic leukemia
57
Which of the following is true of acute lymphoblastic leukemia (ALL)?
massive accumulation of primitive lymphoid appearing cells in bone marrow occurs
58
A 50 year old woman who has been receiving busulfan for 3 years for chronic myelogenous leukemia becomes anemic. Lab tests reveal thrombocytopenia, many peroxidase negative blast cells in PB, bone marrow hypercellular in blast transformation, markedly increased bone marrow TdT. Which of the following complications is this patient most likely to have?
acute lymphocytic leukemia
59
The most common form of childhood leukemia is
acute lymphocytic leukemia
60
Chronic lymphocytic leukemia is defined as a(n):
accumulation of monoclonal B cells with a block in cell maturation
61
Hairy cell leukemia (leukemic reticuloendotheliosis) is:
a chronic leukemia of lymphocytic origin
62
Which of the following is not a characteristic usually associated with hairy cell leukemia?
increased resistance to infection
63
Morphologic variants of plasma cells do not include
Gaucher cells
64
Which of the following bone marrow findings facor the diagnosis of multiple myeloma?
sheaths of immature plasma cells
65
Which of the following have a B cell origin?
Waldenstrom macroglobulinemia
66
Which of the following cells is most likely identified in leasions of mycosis fungoides
T lymphocytes
67
Of the following, the disease most closely associated with cytoplasmic granule fusion is
Chediak Higashi syndrome
68
Which of the following anomalies is an autosomal dominant disorder characterized by irregulary sized inclusions in polymorphonuclear neutrophils, abnormal giant platelets and often thrombocytopenia?
May-Hegglin
69
Of the following, the disease most closely associated with granulocyte hyposegmentation is
Pelger Huet anomaly
70
Which of the following cell types is characteristic of Pelget Huet anomaly is the
pince-nez form
71
Which of the following is associated with the Chediak Higasi syndrome
membrane defect of lysosomes
72
Which of the following is associated with Alder-Reilly inclusions
mucopolysaccaridosis
73
Which of the following is associated with May-Hegglin anomaly?
Dohle bodies and giant platelets
74
A diff was performed on an asymptomatic patient. The diff included 60 neutrophils: 55 of which had 2 lobes and 5 had 3 lobes. There were no other abnormalities. This is consistent with which of the following anomalies?
Pelger Huet
75
The cytoplasmic abnormality of the white blood cell of Alder Reilly anomaly is found in the
lysosomes
76
Of the following, the disease most closely associated with mucopolysaccharidosis is
Alder-Reilly
77
Of the following, the disease most closely associated with glucocerebrosidase deficiency is
Gaucher disease
78
Patients with chronic granulomatous disease suffer from frequent pyogenic infections due to the inability of
neutrophils to kill phagocytized bacteria
79
Of the following, the disease most closely associated with pale blue inclusions in granulocytes and giant platelets is
May Hegglin anomaly
80
An oncology patient has the following results
chemotherapy
81
A leukocyte count and differential on a 40 year old caucasian man revealed WBC 5.4 with 20 segs, 58 lymphs, 20 monos and 2 eos. This represents
absolute neutropenia
82
A leukocyte count and differential on a 40 year old caucasian revealed WBC 5.4 with 20 seg, 58 lymphs, 20 monos and 2 eos. This represents
relative lymphocytosis
83
In synovial fluid, the most characteristic microscopic finding in gout is
monosodium urate crystals
84
Given the following data WBC 8.5, 56 segs, 2 bands, 30 lymphs, eos 6. What is the absolute lymph count?
C. 2550 uL
85
Given the following data WBC 8.5, 56 segs, 2 bands, 30 lymphs, eos 6. What is the absolute eos count?
510 uL
86
Which of the following is the formula for manual white cell count?
number of cells countedxdilutionx10/number of squares counted
87
If a WBC count is performed on a 1:10 dilution and the number of cells counted in 8 squares is 120, the total WBC is
1500uL
88
If a WBC count is performed on a 1:100 DILUTION and the number of cells counted in 8 squares is 50, the total WBC count is
6250 uL
89
An automated leukocyte count is 22.5x10^9. The differential reveals 200 normoblasts/100 leukocytes. What is the actual leukocyte count per microliter?
7500uL
90
A total leukocyte count is 10.0x10^3 and 25 NRBC are seen per 100 leukocytes on the differential. What is the corrected leukocyte count?
8000uL
91
If the total leukocyte count is 20.0x10^3 and 50 NRBC are seen per 100 leukocytes on the differential, what is the corrected leukocyte count
13333uL
92
A blood smear shows 80 nucleated red cells per 100 leukocytes. The total leukocyte count is 18x10^3 uL. The true white cell count expressed in SI units is:
10.0x10^3
93
A mean cellular hemoglobin concentration (MCHC) over 36g/dL is frequently found in
all of the above
94
An unexplained elevation of the prothrombin time (PT) in a 72 year old smoker who has been diagnosed with chronic pulmonary obstructive disease is most likely due to:
elevated HCT
95
Which of the following statements about this field is true?
the large cell on the left is a monocyte
96
The large nucleated cell in the lower right hand side of the image below is a
myelocyte
97
In the image below, the small nucleated cell seen in the lower left corner is a
mature lymphocyte
98
The cells seen in the image below are most consistent with
infectious mono
99
Cell description: size 12 to 16 um, oval, notched, folded over to horseshoe shape, fine lacy chromatin stains light purple-pink, no nucleoli present, cytoplasm is abundant, slate gray, with many fine lilac-colored granules. This cell is a
monocyte
100
The large cell in the center of the image would best be described as:
basophil
101
The large cell indicated by the arrow in image below is a:
Myelocyte
102
A patient is diagnosed as having bacterial septicemia. Which of the following would best describe the expeced change in his peripheral blood?
Granulocytic leukemoid reaction
103
The most characteristic morphologic features of atyical lymphocytes include:
coarse nuclear chromatin and basophilic cytoplasm
104
A bone marrow shows foam cells ranging from 20-100um in size, vaculoted cytoplasm containing sphingomyelin and is faintly PAS+. This cell is most characteristic of:
Niemann Pick disease
105
Bone marrow examination reveals a hypercellular marrow consisting of probably lymphoblasts. The cells stain positively with anti-TdT and anti CD3 and CD7 antibodies; however, the lymphoblass are negative for Sigs, CD19, CD10 (CALLA), Fc, and complement receptors, The most likely diagnosis is:
monosodium urate crystals
106
In synovial fluid, the most characteristic finding in pseudogout is:
calcium pyrophosphate dihydrate crystals
107
In synovial fluid, the most characteristic finding in traumatic arthritis is
hemosiderin-laden macrophages
108
Which of the following stains is most frequently used to differentiate acute myelocytic from acute lymphocytic leukemia?
peroxidase
109
The cell series most readily identified by a positive sudan black B is
myelocytic
110
Which cell type shows the most intense staining with peroxidase
neutrophil
111
Which of the following may be used to stain neutral fats, phospholipids and steroids?
Sudan black B
112
The stain that selectively identifies phospholipid in the membranes of primary and secondary granules within myeloid cells is
Sudan black B
113
Which of the following stains is closely associated with the lysosomal enzyme in promary granules
peroxidase
