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MDL 225 Hematology 2 > WBC - BOC flashcards > Flashcards

WBC - BOC flashcards

1
Q

An increased amount of cytoplasmic basophilia in a blood cell indicates _____.

A

B decreased cytoplasmic maturation

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2
Q

The term “shift to the left” refers to:

A

Immature cell forms in the perpheral blood

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3
Q

A term that means varying degrees of leukocytosis with a shift to the left and occasional nucleated red cells in the peripheral blood is:

A

Leukoerythroblastosis

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4
Q

Cells that produce antibodies and lymphokines are

A

Lymphocytes

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5
Q

The peripheral blood monocyte is an intermediate stage in the formation of the

A

Fibroblast

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6
Q

Specific (secondary) granules of the neutrophilic granulocyte

A

appear first at the myelocyte stage

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7
Q

In normal adult bone marrow, the most common granulocyte is the

A

metamyelocyte

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8
Q

Elevation of the total granulocyte count above 7.7x10^3 is termed

A

absolute neutrophilic leukocytosis

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9
Q

Elevation of the total white cell count above 12x10^3 is termed

A

Leukocytosis

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10
Q

Elevation of the granulocyte percentage above 75% is termed:

A

relative neutrophilic leukocytosis

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11
Q

Elevation of the lymphocyte percentage above 47% is termed

A

relative lymphcytosis

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12
Q

Terminal deoxynucleotidyl transferase (TdT) is a marker found on:

A

lymphblasts

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13
Q

Multipotent stem cells are capable of producing

A

lymphoid and myeloid stem cells

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14
Q

The philadelphia chromosome is formed by a translocation between the:

A

long arm of chromosome 22 and long arm of chromosome 9

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15
Q

Phagocytosis is a function of

A

granulocytes

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16
Q

The white cell feature most characteristic of pernicious anemia is

A

Hypersegmentation

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17
Q

Which of the following conditions is not associated with a high incidence of leukemia

A

Megaloblastic anemia

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18
Q

The M:E ratio in chronic myelocytic leukemia is usually

A

high

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19
Q

In the FAB classification, myelomonocytic leukemia would be

A

M4

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20
Q

Abnormalities found in erythroleukemia include

A

megaloblastoid development

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21
Q

Neutropenia is not usually associated with

A

Hodgkin disease

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22
Q

Auer rods are most likely present in which of the following?

A

Acute myelocytic leukemia

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23
Q

The following results were obtained on a 45 year old man with chills. High WBC, philadelphia neg, toxic gran, dohle bodies and vacuoles

A

Neutrophilic leukemoid reaction

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24
Q

In an uncomplicated case of infectious mononucleosis, which of the following cells are affected?

A

Lymphocytes

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25
Q

The atypical lymphocyte seen in the peripheral smear of patients with infections mono is probably derived from which of the following?

A

B lymphocytes

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26
Q

The disease most frequently present in patients with atypical lymphocytosis and persistently negative tests is

A

CMV infection

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27
Q

Dwarf or micro megakaryocytes may be found in the peripheral blood of patients with

A

myelofibrosis with myeloid metaplasia

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28
Q

Which of the following is associated with pseudo-Pelger Huet anomaly?

A

Myelogenous leukemia

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29
Q

Auer bodies are:

A

predominately found in acute myelogenous leukemia

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30
Q

The absence of the philadelphia chromosome in granulocytic leukemia suggests

A

rapid progression of the disease

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31
Q

Increased numbers of basophils are often seen in

A

chronic myelocytic leukemia

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32
Q

A hypercellular marrow with an M:E ratio of 6:1 is most commonly due to:

A

granulocytic hyperplasia

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33
Q

Which is the most predominant form of secondary hematologic malignancy seen in patients with multiple myeloma

A

Acute myelomonocytic leukemia

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34
Q

In chronic myelocytic leukemia, blood histamine concentrations tend to reflect the

A

number of basophils present

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35
Q

Biochemical abnormalities characteristic of polycythemia vera include

A

increased serum B12 binding capacity

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36
Q

Auer rods:

A

are lysosome and acid phosphatase positive

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37
Q

50-90% myeloblasts in aperipheral blood is typical of which of the following?

A

acute myelocytic leukemia

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38
Q

The M:E ratio in acute myelocytic leukemia is usually

A

high

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39
Q

which of the following is most closely associated with acute promyelocytic leukemia?

A

disseminated intravascular coagulation

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40
Q

which of the following is most closely associated with chronic myelomonocytic leukemia?

A

lysozymuria

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41
Q

The absence of intermediate maturing cells between the blast and mature neutrophil commonly seen in acute myelocytic leukemia and myelodysplastic syndromes is called

A

leukemic hiatus

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42
Q

Which of the following is most closely associated with chronic myelogenous leukemia?

A

Philadelhia chromosome

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43
Q

The bone marrow in the terminal stage of erythroleukemia is often indistinguishable from that seen in

A

acute myelocytic leukemia

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44
Q

A block in the differentiation or maturation of, and an accretion of immature hematopoietic progenitors is a hallmark of:

A

acute myelogenous leukemia

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45
Q

all stages of neutrophils are most likely to be seen in the peripheral blood of a patient with

A

chronic myelocytic leukemia

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46
Q

All of the following conditions are myeloproliferative disorders except

A

Lymphocytic leukemia

47
Q

A patient has a tumor that concentrates erythropoietin. He is most likely to have which of the following types of polycythemia?

A

polycythemia associated with renal disease

48
Q

Which of the following types of polycythemia is most often associated with emphysema?

A

polycythemia, secondary to hypoxia

49
Q

Hemorrhage in polycythemia vera is the result of

A

abnormal platelet function

50
Q

A patient diagnosed with polycythemia vera 5 years ago now has a normal HCT, decreased Hg and microcytic, hypochromic red cells. What is the most probable cause for the current blood situation?

A

phlebotomy

51
Q

A patient has been treated for polycythemia vera for several years. His blood smear now shows oval macros, HJ bodies, hyper segs, large platelets. The most probable cause of this blood picture is

A

Chemotherapy

52
Q

In infectious mononucleosis, lymphocytes tend to be:

A

enlarged and indented by surrounding structures

53
Q

In comparison to malignant lymphoma cells, reactive lymphocytes

A

are morphologically more variable throughout the smear

54
Q

T-cell acute lymphocytic leukemia (ALL) is closely related to:

A

lymphoblastic lymphoma

55
Q

In the FAB classification, ALL is divided into groups according to

A

morphology

56
Q

increased levels of TdT activity are indicative of

A

acute lymphocytic leukemia

57
Q

Which of the following is true of acute lymphoblastic leukemia (ALL)?

A

massive accumulation of primitive lymphoid appearing cells in bone marrow occurs

58
Q

A 50 year old woman who has been receiving busulfan for 3 years for chronic myelogenous leukemia becomes anemic. Lab tests reveal thrombocytopenia, many peroxidase negative blast cells in PB, bone marrow hypercellular in blast transformation, markedly increased bone marrow TdT. Which of the following complications is this patient most likely to have?

A

acute lymphocytic leukemia

59
Q

The most common form of childhood leukemia is

A

acute lymphocytic leukemia

60
Q

Chronic lymphocytic leukemia is defined as a(n):

A

accumulation of monoclonal B cells with a block in cell maturation

61
Q

Hairy cell leukemia (leukemic reticuloendotheliosis) is:

A

a chronic leukemia of lymphocytic origin

62
Q

Which of the following is not a characteristic usually associated with hairy cell leukemia?

A

increased resistance to infection

63
Q

Morphologic variants of plasma cells do not include

A

Gaucher cells

64
Q

Which of the following bone marrow findings facor the diagnosis of multiple myeloma?

A

sheaths of immature plasma cells

65
Q

Which of the following have a B cell origin?

A

Waldenstrom macroglobulinemia

66
Q

Which of the following cells is most likely identified in leasions of mycosis fungoides

A

T lymphocytes

67
Q

Of the following, the disease most closely associated with cytoplasmic granule fusion is

A

Chediak Higashi syndrome

68
Q

Which of the following anomalies is an autosomal dominant disorder characterized by irregulary sized inclusions in polymorphonuclear neutrophils, abnormal giant platelets and often thrombocytopenia?

A

May-Hegglin

69
Q

Of the following, the disease most closely associated with granulocyte hyposegmentation is

A

Pelger Huet anomaly

70
Q

Which of the following cell types is characteristic of Pelget Huet anomaly is the

A

pince-nez form

71
Q

Which of the following is associated with the Chediak Higasi syndrome

A

membrane defect of lysosomes

72
Q

Which of the following is associated with Alder-Reilly inclusions

A

mucopolysaccaridosis

73
Q

Which of the following is associated with May-Hegglin anomaly?

A

Dohle bodies and giant platelets

74
Q

A diff was performed on an asymptomatic patient. The diff included 60 neutrophils: 55 of which had 2 lobes and 5 had 3 lobes. There were no other abnormalities. This is consistent with which of the following anomalies?

A

Pelger Huet

75
Q

The cytoplasmic abnormality of the white blood cell of Alder Reilly anomaly is found in the

A

lysosomes

76
Q

Of the following, the disease most closely associated with mucopolysaccharidosis is

A

Alder-Reilly

77
Q

Of the following, the disease most closely associated with glucocerebrosidase deficiency is

A

Gaucher disease

78
Q

Patients with chronic granulomatous disease suffer from frequent pyogenic infections due to the inability of

A

neutrophils to kill phagocytized bacteria

79
Q

Of the following, the disease most closely associated with pale blue inclusions in granulocytes and giant platelets is

A

May Hegglin anomaly

80
Q

An oncology patient has the following results

A

chemotherapy

81
Q

A leukocyte count and differential on a 40 year old caucasian man revealed WBC 5.4 with 20 segs, 58 lymphs, 20 monos and 2 eos. This represents

A

absolute neutropenia

82
Q

A leukocyte count and differential on a 40 year old caucasian revealed WBC 5.4 with 20 seg, 58 lymphs, 20 monos and 2 eos. This represents

A

relative lymphocytosis

83
Q

In synovial fluid, the most characteristic microscopic finding in gout is

A

monosodium urate crystals

84
Q

Given the following data WBC 8.5, 56 segs, 2 bands, 30 lymphs, eos 6. What is the absolute lymph count?

A

C. 2550 uL

85
Q

Given the following data WBC 8.5, 56 segs, 2 bands, 30 lymphs, eos 6. What is the absolute eos count?

A

510 uL

86
Q

Which of the following is the formula for manual white cell count?

A

number of cells countedxdilutionx10/number of squares counted

87
Q

If a WBC count is performed on a 1:10 dilution and the number of cells counted in 8 squares is 120, the total WBC is

A

1500uL

88
Q

If a WBC count is performed on a 1:100 DILUTION and the number of cells counted in 8 squares is 50, the total WBC count is

A

6250 uL

89
Q

An automated leukocyte count is 22.5x10^9. The differential reveals 200 normoblasts/100 leukocytes. What is the actual leukocyte count per microliter?

A

7500uL

90
Q

A total leukocyte count is 10.0x10^3 and 25 NRBC are seen per 100 leukocytes on the differential. What is the corrected leukocyte count?

A

8000uL

91
Q

If the total leukocyte count is 20.0x10^3 and 50 NRBC are seen per 100 leukocytes on the differential, what is the corrected leukocyte count

A

13333uL

92
Q

A blood smear shows 80 nucleated red cells per 100 leukocytes. The total leukocyte count is 18x10^3 uL. The true white cell count expressed in SI units is:

A

10.0x10^3

93
Q

A mean cellular hemoglobin concentration (MCHC) over 36g/dL is frequently found in

A

all of the above

94
Q

An unexplained elevation of the prothrombin time (PT) in a 72 year old smoker who has been diagnosed with chronic pulmonary obstructive disease is most likely due to:

A

elevated HCT

95
Q

Which of the following statements about this field is true?

A

the large cell on the left is a monocyte

96
Q

The large nucleated cell in the lower right hand side of the image below is a

A

myelocyte

97
Q

In the image below, the small nucleated cell seen in the lower left corner is a

A

mature lymphocyte

98
Q

The cells seen in the image below are most consistent with

A

infectious mono

99
Q

Cell description: size 12 to 16 um, oval, notched, folded over to horseshoe shape, fine lacy chromatin stains light purple-pink, no nucleoli present, cytoplasm is abundant, slate gray, with many fine lilac-colored granules. This cell is a

A

monocyte

100
Q

The large cell in the center of the image would best be described as:

A

basophil

101
Q

The large cell indicated by the arrow in image below is a:

A

Myelocyte

102
Q

A patient is diagnosed as having bacterial septicemia. Which of the following would best describe the expeced change in his peripheral blood?

A

Granulocytic leukemoid reaction

103
Q

The most characteristic morphologic features of atyical lymphocytes include:

A

coarse nuclear chromatin and basophilic cytoplasm

104
Q

A bone marrow shows foam cells ranging from 20-100um in size, vaculoted cytoplasm containing sphingomyelin and is faintly PAS+. This cell is most characteristic of:

A

Niemann Pick disease

105
Q

Bone marrow examination reveals a hypercellular marrow consisting of probably lymphoblasts. The cells stain positively with anti-TdT and anti CD3 and CD7 antibodies; however, the lymphoblass are negative for Sigs, CD19, CD10 (CALLA), Fc, and complement receptors, The most likely diagnosis is:

A

monosodium urate crystals

106
Q

In synovial fluid, the most characteristic finding in pseudogout is:

A

calcium pyrophosphate dihydrate crystals

107
Q

In synovial fluid, the most characteristic finding in traumatic arthritis is

A

hemosiderin-laden macrophages

108
Q

Which of the following stains is most frequently used to differentiate acute myelocytic from acute lymphocytic leukemia?

A

peroxidase

109
Q

The cell series most readily identified by a positive sudan black B is

A

myelocytic

110
Q

Which cell type shows the most intense staining with peroxidase

A

neutrophil

111
Q

Which of the following may be used to stain neutral fats, phospholipids and steroids?

A

Sudan black B

112
Q

The stain that selectively identifies phospholipid in the membranes of primary and secondary granules within myeloid cells is

A

Sudan black B

113
Q

Which of the following stains is closely associated with the lysosomal enzyme in promary granules

A

peroxidase

MDL 225 Hematology 2 (6 decks)

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