WBC - BOC flashcards
An increased amount of cytoplasmic basophilia in a blood cell indicates _____.
B decreased cytoplasmic maturation
The term “shift to the left” refers to:
Immature cell forms in the perpheral blood
A term that means varying degrees of leukocytosis with a shift to the left and occasional nucleated red cells in the peripheral blood is:
Leukoerythroblastosis
Cells that produce antibodies and lymphokines are
Lymphocytes
The peripheral blood monocyte is an intermediate stage in the formation of the
Fibroblast
Specific (secondary) granules of the neutrophilic granulocyte
appear first at the myelocyte stage
In normal adult bone marrow, the most common granulocyte is the
metamyelocyte
Elevation of the total granulocyte count above 7.7x10^3 is termed
absolute neutrophilic leukocytosis
Elevation of the total white cell count above 12x10^3 is termed
Leukocytosis
Elevation of the granulocyte percentage above 75% is termed:
relative neutrophilic leukocytosis
Elevation of the lymphocyte percentage above 47% is termed
relative lymphcytosis
Terminal deoxynucleotidyl transferase (TdT) is a marker found on:
lymphblasts
Multipotent stem cells are capable of producing
lymphoid and myeloid stem cells
The philadelphia chromosome is formed by a translocation between the:
long arm of chromosome 22 and long arm of chromosome 9
Phagocytosis is a function of
granulocytes
The white cell feature most characteristic of pernicious anemia is
Hypersegmentation
Which of the following conditions is not associated with a high incidence of leukemia
Megaloblastic anemia
The M:E ratio in chronic myelocytic leukemia is usually
high
In the FAB classification, myelomonocytic leukemia would be
M4
Abnormalities found in erythroleukemia include
megaloblastoid development
Neutropenia is not usually associated with
Hodgkin disease
Auer rods are most likely present in which of the following?
Acute myelocytic leukemia
The following results were obtained on a 45 year old man with chills. High WBC, philadelphia neg, toxic gran, dohle bodies and vacuoles
Neutrophilic leukemoid reaction
In an uncomplicated case of infectious mononucleosis, which of the following cells are affected?
Lymphocytes
The atypical lymphocyte seen in the peripheral smear of patients with infections mono is probably derived from which of the following?
B lymphocytes
The disease most frequently present in patients with atypical lymphocytosis and persistently negative tests is
CMV infection
Dwarf or micro megakaryocytes may be found in the peripheral blood of patients with
myelofibrosis with myeloid metaplasia
Which of the following is associated with pseudo-Pelger Huet anomaly?
Myelogenous leukemia
Auer bodies are:
predominately found in acute myelogenous leukemia
The absence of the philadelphia chromosome in granulocytic leukemia suggests
rapid progression of the disease
Increased numbers of basophils are often seen in
chronic myelocytic leukemia
A hypercellular marrow with an M:E ratio of 6:1 is most commonly due to:
granulocytic hyperplasia
Which is the most predominant form of secondary hematologic malignancy seen in patients with multiple myeloma
Acute myelomonocytic leukemia
In chronic myelocytic leukemia, blood histamine concentrations tend to reflect the
number of basophils present
Biochemical abnormalities characteristic of polycythemia vera include
increased serum B12 binding capacity
Auer rods:
are lysosome and acid phosphatase positive
50-90% myeloblasts in aperipheral blood is typical of which of the following?
acute myelocytic leukemia
The M:E ratio in acute myelocytic leukemia is usually
high
which of the following is most closely associated with acute promyelocytic leukemia?
disseminated intravascular coagulation
which of the following is most closely associated with chronic myelomonocytic leukemia?
lysozymuria
The absence of intermediate maturing cells between the blast and mature neutrophil commonly seen in acute myelocytic leukemia and myelodysplastic syndromes is called
leukemic hiatus
Which of the following is most closely associated with chronic myelogenous leukemia?
Philadelhia chromosome
The bone marrow in the terminal stage of erythroleukemia is often indistinguishable from that seen in
acute myelocytic leukemia
A block in the differentiation or maturation of, and an accretion of immature hematopoietic progenitors is a hallmark of:
acute myelogenous leukemia
all stages of neutrophils are most likely to be seen in the peripheral blood of a patient with
chronic myelocytic leukemia
All of the following conditions are myeloproliferative disorders except
Lymphocytic leukemia
A patient has a tumor that concentrates erythropoietin. He is most likely to have which of the following types of polycythemia?
polycythemia associated with renal disease
Which of the following types of polycythemia is most often associated with emphysema?
polycythemia, secondary to hypoxia
Hemorrhage in polycythemia vera is the result of
abnormal platelet function
A patient diagnosed with polycythemia vera 5 years ago now has a normal HCT, decreased Hg and microcytic, hypochromic red cells. What is the most probable cause for the current blood situation?
phlebotomy
A patient has been treated for polycythemia vera for several years. His blood smear now shows oval macros, HJ bodies, hyper segs, large platelets. The most probable cause of this blood picture is
Chemotherapy
In infectious mononucleosis, lymphocytes tend to be:
enlarged and indented by surrounding structures
In comparison to malignant lymphoma cells, reactive lymphocytes
are morphologically more variable throughout the smear
T-cell acute lymphocytic leukemia (ALL) is closely related to:
lymphoblastic lymphoma
In the FAB classification, ALL is divided into groups according to
morphology
increased levels of TdT activity are indicative of
acute lymphocytic leukemia
Which of the following is true of acute lymphoblastic leukemia (ALL)?
massive accumulation of primitive lymphoid appearing cells in bone marrow occurs
A 50 year old woman who has been receiving busulfan for 3 years for chronic myelogenous leukemia becomes anemic. Lab tests reveal thrombocytopenia, many peroxidase negative blast cells in PB, bone marrow hypercellular in blast transformation, markedly increased bone marrow TdT. Which of the following complications is this patient most likely to have?
acute lymphocytic leukemia
The most common form of childhood leukemia is
acute lymphocytic leukemia
Chronic lymphocytic leukemia is defined as a(n):
accumulation of monoclonal B cells with a block in cell maturation
Hairy cell leukemia (leukemic reticuloendotheliosis) is:
a chronic leukemia of lymphocytic origin
Which of the following is not a characteristic usually associated with hairy cell leukemia?
increased resistance to infection
Morphologic variants of plasma cells do not include
Gaucher cells
Which of the following bone marrow findings facor the diagnosis of multiple myeloma?
sheaths of immature plasma cells
Which of the following have a B cell origin?
Waldenstrom macroglobulinemia
Which of the following cells is most likely identified in leasions of mycosis fungoides
T lymphocytes
Of the following, the disease most closely associated with cytoplasmic granule fusion is
Chediak Higashi syndrome
Which of the following anomalies is an autosomal dominant disorder characterized by irregulary sized inclusions in polymorphonuclear neutrophils, abnormal giant platelets and often thrombocytopenia?
May-Hegglin
Of the following, the disease most closely associated with granulocyte hyposegmentation is
Pelger Huet anomaly
Which of the following cell types is characteristic of Pelget Huet anomaly is the
pince-nez form
Which of the following is associated with the Chediak Higasi syndrome
membrane defect of lysosomes
Which of the following is associated with Alder-Reilly inclusions
mucopolysaccaridosis
Which of the following is associated with May-Hegglin anomaly?
Dohle bodies and giant platelets
A diff was performed on an asymptomatic patient. The diff included 60 neutrophils: 55 of which had 2 lobes and 5 had 3 lobes. There were no other abnormalities. This is consistent with which of the following anomalies?
Pelger Huet
The cytoplasmic abnormality of the white blood cell of Alder Reilly anomaly is found in the
lysosomes
Of the following, the disease most closely associated with mucopolysaccharidosis is
Alder-Reilly
Of the following, the disease most closely associated with glucocerebrosidase deficiency is
Gaucher disease
Patients with chronic granulomatous disease suffer from frequent pyogenic infections due to the inability of
neutrophils to kill phagocytized bacteria
Of the following, the disease most closely associated with pale blue inclusions in granulocytes and giant platelets is
May Hegglin anomaly
An oncology patient has the following results
chemotherapy
A leukocyte count and differential on a 40 year old caucasian man revealed WBC 5.4 with 20 segs, 58 lymphs, 20 monos and 2 eos. This represents
absolute neutropenia
A leukocyte count and differential on a 40 year old caucasian revealed WBC 5.4 with 20 seg, 58 lymphs, 20 monos and 2 eos. This represents
relative lymphocytosis
In synovial fluid, the most characteristic microscopic finding in gout is
monosodium urate crystals
Given the following data WBC 8.5, 56 segs, 2 bands, 30 lymphs, eos 6. What is the absolute lymph count?
C. 2550 uL
Given the following data WBC 8.5, 56 segs, 2 bands, 30 lymphs, eos 6. What is the absolute eos count?
510 uL
Which of the following is the formula for manual white cell count?
number of cells countedxdilutionx10/number of squares counted
If a WBC count is performed on a 1:10 dilution and the number of cells counted in 8 squares is 120, the total WBC is
1500uL
If a WBC count is performed on a 1:100 DILUTION and the number of cells counted in 8 squares is 50, the total WBC count is
6250 uL
An automated leukocyte count is 22.5x10^9. The differential reveals 200 normoblasts/100 leukocytes. What is the actual leukocyte count per microliter?
7500uL
A total leukocyte count is 10.0x10^3 and 25 NRBC are seen per 100 leukocytes on the differential. What is the corrected leukocyte count?
8000uL
If the total leukocyte count is 20.0x10^3 and 50 NRBC are seen per 100 leukocytes on the differential, what is the corrected leukocyte count
13333uL
A blood smear shows 80 nucleated red cells per 100 leukocytes. The total leukocyte count is 18x10^3 uL. The true white cell count expressed in SI units is:
10.0x10^3
A mean cellular hemoglobin concentration (MCHC) over 36g/dL is frequently found in
all of the above
An unexplained elevation of the prothrombin time (PT) in a 72 year old smoker who has been diagnosed with chronic pulmonary obstructive disease is most likely due to:
elevated HCT
Which of the following statements about this field is true?
the large cell on the left is a monocyte
The large nucleated cell in the lower right hand side of the image below is a
myelocyte
In the image below, the small nucleated cell seen in the lower left corner is a
mature lymphocyte
The cells seen in the image below are most consistent with
infectious mono
Cell description: size 12 to 16 um, oval, notched, folded over to horseshoe shape, fine lacy chromatin stains light purple-pink, no nucleoli present, cytoplasm is abundant, slate gray, with many fine lilac-colored granules. This cell is a
monocyte
The large cell in the center of the image would best be described as:
basophil
The large cell indicated by the arrow in image below is a:
Myelocyte
A patient is diagnosed as having bacterial septicemia. Which of the following would best describe the expeced change in his peripheral blood?
Granulocytic leukemoid reaction
The most characteristic morphologic features of atyical lymphocytes include:
coarse nuclear chromatin and basophilic cytoplasm
A bone marrow shows foam cells ranging from 20-100um in size, vaculoted cytoplasm containing sphingomyelin and is faintly PAS+. This cell is most characteristic of:
Niemann Pick disease
Bone marrow examination reveals a hypercellular marrow consisting of probably lymphoblasts. The cells stain positively with anti-TdT and anti CD3 and CD7 antibodies; however, the lymphoblass are negative for Sigs, CD19, CD10 (CALLA), Fc, and complement receptors, The most likely diagnosis is:
monosodium urate crystals
In synovial fluid, the most characteristic finding in pseudogout is:
calcium pyrophosphate dihydrate crystals
In synovial fluid, the most characteristic finding in traumatic arthritis is
hemosiderin-laden macrophages
Which of the following stains is most frequently used to differentiate acute myelocytic from acute lymphocytic leukemia?
peroxidase
The cell series most readily identified by a positive sudan black B is
myelocytic
Which cell type shows the most intense staining with peroxidase
neutrophil
Which of the following may be used to stain neutral fats, phospholipids and steroids?
Sudan black B
The stain that selectively identifies phospholipid in the membranes of primary and secondary granules within myeloid cells is
Sudan black B
Which of the following stains is closely associated with the lysosomal enzyme in promary granules
peroxidase
