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FU17 Hematology > WBC CBC > Flashcards

WBC CBC Flashcards

1
Q

complex process where blood cells form, proliferate, differentiate, and mature

A

hematopoiesis

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2
Q

where does hematopoiesis occur in adults?

A

bone marrow

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3
Q

originator stem cell of all blood

A

multi potential stem cell

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4
Q

lymphoid stem cell line

A

lymphocyte (B and T cells)

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5
Q

myeloid cell line

A

basophils, eosinophils, neutrophils, monocytes, platelets

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6
Q

total number of leukocytes

A

WBC

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7
Q

percentages of different types of blood cells

A

differential

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8
Q

normal value of WBC

A

4500-10500/mm3

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9
Q

bacterial infection = ____ WBC

A

HIGH

leukocytosis

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10
Q

viral infection = ___ WBC

A

LOW

leukopenia

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11
Q

leukocytosis value

A

> 10,000/mm3

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12
Q

leukopenia value

A

< 4000/mm 3

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13
Q

leukocytosis

A

elevated WBC

increase in ONE type of cell (infection, leukemia, drugs -steroids)

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14
Q

leukopenia

A

low WBC

viral infection, bone marrow depression, hyperspelnism

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15
Q

leukomoid reaction

A

marked increase in WBC (50,000 - 100,000 /mm3)

due to infection but increase is only temporary

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16
Q

panic values for total WBC

A

<500 or >30,000

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17
Q

“polys” listed in differential

A

bands, segmented neutrophils, eosinophils and basophils

aka granulocytes

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18
Q

what leukocytes are most abundant in a diff

A

segs/polys (neutrophils) 50-70%

followed by lymphocytes (20-30%)

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19
Q

absolute count

A

obtained by multiplying relative % by total WBC count

used when you need to know actual numbers (i.e chemotherapy)

20
Q

types of neutrophils

A

segmented (mature)

bands (immature)

21
Q

band neutrophil

A

00-5% of total WBC

nucleus is NOT segmented, increases during infections

22
Q

“left shift”

A

increased in bands on a CBC

seen in association with increased WBC in infection

23
Q

segmented neutrophils

A

most numerous of all WBC (50-70%)

primary defense against microbes

enzymes are found in granules that responsible for body tissue

24
Q

hypersegmented neutrophil

A

mature neutrophil with more than 5 lobes

25
Q

conditions that might have hyperhsegmented neutrophil

A

mesoblastic anemia
vitamin b12 /folate deficiencies
hereditary

26
Q

ANC

A

count used to determine levels of neutrophil

determines if safe to give chemo

27
Q

ANC value

low risk of infection

A

1,000-1,5000

28
Q

ANC value

moderate risk of infection

29
Q

ANC value

high risk of infection

30
Q

eosinophil

levels and function

A

0-5% of WBC

parasite (worm) defense, allergic/hypersensitivity rex

granules have histamin

31
Q

basophils

value and function

A

0-1% of WBC

grnules have heparin and histamine

increased in leukemia and chronic inflammation

32
Q

lymphocytes

value and function

A

20-40% of EBC

small, mononuclear, no granules

high in viral infections

source if Igs (B cells) and cellular immunity (T cells)

33
Q

phagocytic cells that preform scavenger functions

A

monocytes

produce antiviral Interferon

0-7% of CBC

34
Q

abnormal findings on CBC (3)

A
  1. immature WBCs
  2. inclusion bodies
  3. Morphology changes
35
Q

blast cells

A

should never be seen on peripheral blood smear

usually indicate leukemia

36
Q

cytoplasmic infusions

A

WBC abnormalities associated with infection

  1. toxic granulation
  2. Dohle bodies
  3. Auer rods
37
Q

toxic granualtion (4)

A

black/purple cytoplasm granules

found in infection, inflammation, burns, drug poisoning

38
Q

Dohle bodies

A

lg. blue masses in cytoplasm of neutrophils

occur in myeloproliferative syndromes, infections, burns, inflammatory diseases

39
Q

Auer rods

A

cytoplasm of BLAST cells

rod-like, purple inclusions

pathognomonic of AML

40
Q

other morphology changes seen on WBC

A
  1. smudge cells

2. atypical lymphocytes

41
Q

smudge cells

A

disintegrating nucleus of ruptured WBC

common in CLL

42
Q

atypical lumphoctes

A

reactive or activated lymphocyte

role unknown, immune cell

most often seen in infectious mono

43
Q

Infectious mononucleosis will exhibit

A

lymphocytosis and atypical lymphocytes

44
Q

platelets are produced in the _____ from ____

A

bone marrow from megakaryocytic

no nucleus, survive 8-10 days

45
Q

normal platelet levels

A

140,000 - 400,000 /mm3

46
Q

panic value of platelets

A

< 20,000

spontaneous bleeding

FU17 Hematology (10 decks)

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