Intro To Coagulation FRAN Flashcards
Arrest of bleeding depends on
Platelet plug formation
Elaboration of stable fibrin clot
Combined activity of vasculature, platelet, and plasma factors
Primary hemostasis
Platelet plug formation
Depends on normal platelet number and function
Secondary hemostasis
Activation of clotting cascade
Deposition and stabilization of fibrin
Tertiary hemostasis
Dissolution of fibrin clot
Dependent on plasminogen
First response to vessel injury
Release of vascular factors to reduce flow of blood from trauma by local vasoconstrction
Which part of coagulation cascade is tested using a PTT?
INTRINSIC pathway
Triggered by blood vessel injury
Which part of coagulation cascade is tested using a PT?
EXTRINSIC pathway
Activated by tissue factor release
Key result of coagulation pathway
Prothrombin converted to thrombin
Thrombin converts fibrinogen to fibrin
Role of factor XIII in hemostasis
Stabilizes fibrin clot by cross linking fibrin and platelets
INR
International normalize ratio
A standardization of PT, allows them to be compared
Calculated by dividing patients PT by the mean normal PT
Test that measures factors specific to intrinsic and common pathways
APTT
Measured in seconds
Determines how long it takes to clot
Screening test that determines a specific factor that is deficient
Factor assay
Patient with heparin, what test
PTT
Patient with Coumadin
PT/INR
Laboratory tests used in DIC
Fibrinogen test
D-Dimer
Fibrin split products
