Iron Studies And Blood Bank Flashcards
What is used to transport iron around blood
Transferrin
Iron outside of blood is stored in what type of cells
Ferritin
Serum iron
Measures amount of iron bound to transferrin in serum
W/ iron deficiency = LOW
TIBC
Measures binding capacity of transferrin
Increased in patients with iron deficient anemia (more desperate – less iron you actually have, more “room” to bind)
Transferrin saturation
Index of iron saturation
Less iron you have more capacity you have to bind – SO low saturation in Fe deficient anemia
Ferritin lab
Iron storage protein
Studied as a reflection of iron storage in the body
LOW in Fe def. anemia
Direct way to study iron stores in body
Direct liver or bone marrow bx
Not done bc invasive
Use Ferritin lab instead
Hemosidrin
Storage of iron in the liver and bone marrow
Studied in direct biopsy and stained with Prussia Blue
Most basic serologic test
Agglutination
Particulate coated with Ag
Ab cross link the antigen, clumping occurs
Type A blood
A antigen on blood - doesn’t react
Anti B antibodies (will react if given B blood)
Can receive A, O
Type B
B Ag on RBCs
Anti-A Abs (will react)
Can receive: B, O
Type AB
Both A and B antigens on surface
No antibodies
UNIVERSAL RECEIVER
Type O
No A or B antigens on surface
Has A and B antibodies in serum
UNIVERSAL DONOR
D antigen
Rh factor
D+ = present (Rh +)
If D-, exposure to D will have terrible results
Other Ags in blood
Rh Duff MNS Kell Kidd P
Detected by COOMBS or IAT
