WBC

Question 1

What does basophils release to cause allergy ?

Answer 1

6 things

Histamine 
Heparin 
Serotonin 
SRA Slow reactive anaphylaxis 
Lysosomal enzymes 
Bradykinine

Question 2

Where does B and T cells preprocessing happens ?

Answer 2

T cells in thymus

B cells
In mid feta life: liver
In late fetal life and after birth: bone marrow

Question 3

How does the TB become chronic ?

Answer 3

It has a coats that is resistant to lysosomal digestion

Question 4

Describe activation of macrophages and neutrophils

Answer 4

By cytokines meanly

Activated Macrophage will release TNF ,IL1 , CSF GM G M

These will activate fibroblast,lymphocytes,endothelial cells
Then these cells realse CSF GM G M

CSF GM G M will stimulate bone marrow to make granulocytes and monocytes

Question 5

Describe B and T preprocessing

Answer 5

T and B cells gain:

1- diversity against different Ags
2- differ self from non self

Question 6

Reticulo endothelial system

A-Made by what ?
B-Where is it ?

Answer 6

Its rule is 3
3 cells
3 sites

A

Monocytes
Macrophages
Specialized endothelial cells

B

Bone marrow
Spleen
Lymph node

Question 7

MJB major basic protein fight what ?

Answer 7

It is larvacidal

Question 8

Wbcs characteristic

Answer 8

M

D

A

C

P

A

Md اكبا

Question 9

Strongest APCs

Answer 9

Dendritic cell

Question 10

Examples of chemotactic factors ?

Answer 10

Toxins of viruses and bacteria

Products of coagulation system

Products of complements system

Degenerative products of inflamed tissue

Question 11

Pus consistent of what ?

Answer 11

Necrotic tissue

Dead neutrophils

Dead macrophages

Tissue fluids

Question 12

Anti microbial effect of wbcs includes what ?

Answer 12

1-lysosomal enzymes

Such as : myloperoxidase

2-peroxisomes

Question 13

How does myloperoxidase enzyme works ???

Answer 13

H2O2 + cl = hypochlorite

H2O2 يعتبر toxic

Question 14

How does peroxisomes works ???

Answer 14

It has bactriocidal  agents 
Such as 
Superoxide 
Hydrogen peroxide 
Hydroxyl ions

Question 15

Reactive oxygen fight what ?

Answer 15

It is very fatal against parasites

Question 16

Where does B and T cells preprocessing happens ?

Answer 16

T cells in thymus

B cells
In mid fetal life: liver
In late fetal life and after birth: bone marrow

Question 17

Describe lymphocytes clone

Answer 17

Ag will be recognized by T cells or B cells or macrophages

These cells gets activated
T cells will clone to Ag specific cells
B cells will clone to Ag specific cells

Activated macrophages activate B and T cells

AB + clones of T cells fight the Ag

Question 18

Lines of defense

Answer 18

4 cell lines

1 fixes macrophages
2 neutrophils
3 monocytes in blood 8 hours then enter tissue to become macrophages

4 production of granulocytes and monocytes
Takes 3 to 4 days

Question 19

Precentage

Answer 19

Total 4000-11000

Neutrophils 50-70%

Lymphocytes 20-40%

Monocytes 3-8%

Eosinophils 1-4%

Basophils 0-1%

Question 20

Describe B and T preprocessing

Answer 20

T and B cells gain:

1- diversity against different Ags
2- differ self from non self

Question 21

How is basophil allergic ?

Answer 21

It has IgE attached to its surface

Question 22

How is eosinophil anti allergic ?

Answer 22

1- basophils and mast cells gives eosinophils chemotactic factor

Then eosinophils go and detoxify inflammatory mediators of theses cells

2-phagocytose and destroy allergen-Ab complex

Question 23

Esinophil .

How is it parastic ?

Answer 23

It has
Hydrolytic enzymes
Reactive form of oxygen
MBP major basic protein