Leukopenia

Question 1

Leukopenia results commonly form

Answer 1

Decrease granulocyte because they the the most numerous circulating WBC

Question 2

Pathogenisis of neutopenia

Answer 2

1-decrese production a-bone marrow hypoplasia (chemotherapy, plastic anemia)

b-replacment of bone marrow by tumor
c-suppretion in neutrophil only in certain drug and in neo plastic proliferation of cytotoxic T cell and NK

2-increase destruction a-spenomegaly
b-increase perifral use in chronic infection

Question 3

Pathogenisis of EBV

Answer 3

Effect on virus on B-cell lead to either 1-lytic of B- cell and spread of viral
2-stay and persist in latent form

–later on B-Cell will be activated and proliferate as a result of action protein lead to production on unusual AB like AB against sheep Red blood cell

–The T-lymphocyte control the proliferation of the virus effected B-cell

–B-cell will first secreter igM and later on igG

Question 4

The main morphological features of EBV

Answer 4

Atypical lymphocytes

Question 5

Diagnosis of EBV

Answer 5

Atypical lymphocytes
Positive monospot test
EBV specific AB

Question 6

EBV and b-cell lymphoma

Answer 6

In PT with lacking of t-cell the EBV will stimulate b-cell proliferation which is un control this polyclonal proliferation will transform to B-cell lymphoma

Question 7

Reactive lymphadenitis

Answer 7

1-acute non specific lymphadenitis(localized, genalize)

2-chronic Nonspecific lymphadenitis (follicular hyperplasia,paracortical hyperplasia, sinus histocytosis)

Question 8

Causes of follicular hyperplasia

Answer 8

RA
Toxoplasmosis
Syphilis
Hiv

Question 9

Causes of paracortical hyperplasia

Answer 9

Viral infections
Vaccination (CMV)
Drug(phenytoin)

Question 10

Causes of sinus histocytosis

Answer 10

Cancer