Warfarin Flashcards
1
Q
What is the mechanism of action of warfarin?
A
- blocks epoxide reductase enzyme
- blocks vitamin K production
- vitamin K is needed to activate ;
Factor 2, 7 , 9 , 11
2
Q
which coagulation factors does warfarin effect?
A
- 2
- 7
- 9
- 11
3
Q
How is warfarin monitored?
A
- Prothrombin time
- measure of how well the
- extrinsic pathway
- common pathway
are functioning
4
Q
Normal INR?
A
< 1.1
5
Q
Warfarin INR?
A
2 < INR < 3
6
Q
Route of administeration?
A
Oral
7
Q
When is warfarin indicated?
A
- 2nd line for ; PE and DVT
- AF
- Valvular replacement
8
Q
Name 3 adverse effects of warfarin?
A
- haemorrhage
- teratogenic
- skin necrosis
9
Q
why is warfarin CI in pregnancy?
A
- congenital heart defects
2. brain malformation
10
Q
What is the antidote of warfarin OD?
A
- FFP - fresh frozen plasma containing coagulation factors
2. IV vitamin K
