heparin induced thrombocytopenia

Question 1

explain the immune pathophysiology behind HIT?

Answer 1

1. antibodies from against plate factor 4 and heparin
2. antibodies bind to PF4-heparin complexes
3. cross link receptors and cause platelet activation

Question 2

When does HIT develop in treatment?

Answer 2

5 - 10 days after treatment

Question 3

name 3 clinical features of HIT?

Answer 3

1. 50% reduction in platelets
2. thrombosis - prothrombotic condition
3. skin allergy