unfractionated Heparin Flashcards
1
Q
what is the mechanism of action?
A
- activates anti thrombin III
- inhibits Factor 10, 9 ,11 and 12 in the coagulation cascade
- prevents coagulation
2
Q
administration?
A
IV
3
Q
duration of action?
A
Short
4
Q
Name 3 side effects of standard/unfractionated heparin?
A
- bleeding
- heparin induced thrombocytopaenia
- osteoporosis
- hyperkalaemia - inhibits aldosterone secretion
5
Q
How is it monitored?
A
Activated partial thromboplastin time
6
Q
How is APTT calculated?
A
measures clotting via;
- intrinsic pathway
- common pathway
7
Q
normal APTT?
A
30 - 40 seconds
8
Q
Heparin APTT?
A
50 - 90 secs (1.5 - 2.5 x baseline)
9
Q
What is a heparin reversal agent called?
A
Protamine Sulphate
10
Q
which coagulation factors are affected by standard heparin?
A
factors 10,9,11 and 12
