Warfarin

Question 1

Class

Answer 1

Oral anticoagulant

Question 2

Actions

Answer 2

Inhibits blood

coagulation

Question 3

Mechanism of action

Answer 3

Inhibits reduction of
vitamin K and thus
prevents y-carboxylation
of the glutamate residues
in factors 2, 7, 9 and 10.

Question 4

Clinical use

Answer 4

Treat deep vein
thrombosis
Pulmonary embolism
Prevent embolization
in atrial fibrillation

Question 5

Adverse effects

Answer 5

Bleeding. Treated by giving natural vitamin K or fresh plasma/coagulation factor concentrates

Question 6

What is replacing Warfin

Answer 6

non-vitamin K antagonist oral anticoagulants.

Question 7

What is Warfrin

Answer 7

: An anticoagulant (A vitamin K antagonist)

Question 8

What do i use warfarin to treat

Answer 8

the prevention and treatment of thromboembolic disease including venous thrombosis, thromboembolism, and pulmonary embolism as well as for the prevention of ischemic stroke in patients with atrial fibrillation (AF).

Question 9

what happens if you give warfarin to preggers women

Answer 9

foetal bleeding, spontaneous abortion, and neonatal death

Question 10

why if warfarin bad for preggers women

Answer 10

because it can cross the placental barriers

Question 11

action of warfarin

Answer 11

inhibits vitamin K reductase, reducing levels of the reduced form of vitamin K. lowering the production of coagulation factors 2 7 9 and 10. as well as anticoagilant proteins C and S

Question 12

what does vit K do

Answer 12

. As vitamin K is required for the production of coagulation factors II, VII, IX, and X and anticoagulant proteins C and S

Question 13

depression of vitamin K-dependent coagulation factors 2 7 and 10 result in what

Answer 13

decreased prothrombin levels , decreased thrombin generation and reduced ability to form a clot.