Digoxin Flashcards

1
Q

Class

A

Cardiac stimulant

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2
Q

Actions

A
Slows heart
Slows AV conduction
Prolongs AV node
refractory period
Increases force of
contraction in failing
heart
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3
Q

Mechanism of action

A
Inhibits Na+/K+ ATPase in
plasma membrane
Increased intracellular Na+
reduces Ca2+ extrusion
thus increasing Ca2+
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4
Q

Clinical use

A

Atrial fibrillation

Heart failure

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5
Q

Adverse effects

A

Dysrhythmias
Yellow vision
Nausea
Vomiting

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6
Q

what is Digoxin

A

A cardiac glycoside (A Sodium potassium ATPase inhibitor)

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7
Q

what is digoxin used to treat

A

used to treat congestive heart failure, and supraventricular arrhythmias

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8
Q

mode of action of Digoxin

A

via inhibition of the Na-K-ATPase membrane pump, resulting in an increase in intracellular sodium. This causes in turn the sodium calcium exchanger (NCX) to extrude the sodium and pump in more calcium.

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9
Q

what happens as a result of the alteration in calcium concentration?

A

is thought to promote activation of contractile proteins (e.g., actin, myosin).

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10
Q

other than the meberance pumpl, wha else does digoxin act on

A

Digoxin also acts on the electrical activity of the heart, increasing the slope of phase 4 depolarization, shortening the action potential duration, and decreasing the maximal diastolic potential.

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11
Q

current usage?

A

Still used in Atrial Fibrillation, but now very much third line treatment option

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12
Q

is digoxin still used in heart failure

A

no because better drugs aavailabe

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