Bendroflumethiazide

Question 1

Class

Answer 1

Diuretic

Question 2

Actions

Answer 2

Causes moderate
degree of diuresis by
inhibiting NaCl
reabsorption

Question 3

Mechanism of action

Answer 3

Inhibits the Na+/Cl- co-
transporter in the luminal
membrane of the distal
convoluted tubule

Question 4

Clinical use

Answer 4

Hypertension
Mild heart failure
Nephrogenic
diabetes insipidus
Kidney stones

Question 5

Adverse effects

Answer 5

Potassium loss
Metabolic alkalosis
Hyperuricaemia
Increased insulin
requirement
Erectile dysfunction

Question 6

What is Bendroflumethiazide

Answer 6

a Thiazide diuretic

Question 7

what does Bendroflumethiazide do

Answer 7

diuretic increases urinary excretion of water, and can cause blood vessel dilatation. It has two mechanisms of action,

Question 8

two mecanisms for action of Bendroflumethiazide

Answer 8

1) It inhibits the Na-Cl cotransporter, blocking active chloride reabsorption in the early distal tubule. This results in an increase in the excretion of sodium, chloride, and water.
2) It inhibits sodium ion transport across the renal tubular epithelium through binding to the thiazide sensitive sodium-chloride transporter. This results in an increase in potassium excretion via the sodium-potassium exchange mechanism.

Question 9

the antihypertensive mechanism of Bendroflumethiazide

Answer 9

1) inhibiting carbonic anhydrases in the smooth muscle

2) activating the large-conductance calcium-activated potassium (KCa) channel, in the smooth muscle.

Question 10

wtf

Answer 10

It may act although it may be mediated

Question 11

common useage?

Answer 11

Much less commonly used following recent hypertension guidelines.