Ramipril, Lisinopril, Enalapril, and Captopril Flashcards
C Class
ACE inhibitor
C Actions
Lowers blood pressure
by decreasing
vasoconstrictor tone
Reduces cardias load
C Mechanism of action
Inhibits angiotensin- converting enzyme thus reducing synthesis of vasoconstrictor angiotensin 2. This decreases aldosterone secretion Results in increased salt and water excretion which reduces plasma volume and cardiac load
C Clinical use
Hypertension Heart failure Ventricular dysfunction following myocardial infarction Diabetic nephropathy
C Adverse effects
Hypotension
Dry cough
Angioedema
Renal failure
What class are Ramipril, Lisinopril, Enalapril, and Captopril in
competitive inhibitor of angiotensin-converting enzyme (ACE)
what do the ACE’s do to angiotensin I
convert it into angiotensin Il
what does ATII do
regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS).
how does angiotensin Il increase blood pressure
1) Stimulation of secretion of aldosterone from the adrenal cortex
2) Stimulation of Vasopression secretion from the posterior pituitary gland.
3) Through direct arterial vasoconstriction.
how does ATII induce the thirst response?
via stimulation of hypothalamic neurons
what are the two isoforms of ACE
somatic isoform, and a testicular isoform.
what are the two functionally active domans of somatic ACE
N and C.
what does the C domain do
predominantly involved in blood pressure regulation
what does the N domain do
while the N-domain plays a role in hematopoietic stem cell differentiation and proliferation
what does the ACE inhibitor do to the domains
ACE inhibitors bind to and inhibit the activity of both domains
