warfarin Flashcards

1
Q

type of drug

A

oral anti-coagulant

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2
Q

prevents

A

vitamin K re-activation

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3
Q

how does it prevent it

A

inhibit vit K epoxide reductase complex (VKORC)

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4
Q

active vitamin K is required for

A

synthesis of clotting factors

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5
Q

warfarin is metabolized by

A

CYP2C9

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6
Q

genetic variation in CYP2C9 reduces

A

warfarin metabolism (increased bleeding risk)

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7
Q

genetic variation in the VKORC1 can increase or decrease

A

warfarin sensitivity

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