warfarin Flashcards
1
Q
type of drug
A
oral anti-coagulant
2
Q
prevents
A
vitamin K re-activation
3
Q
how does it prevent it
A
inhibit vit K epoxide reductase complex (VKORC)
4
Q
active vitamin K is required for
A
synthesis of clotting factors
5
Q
warfarin is metabolized by
A
CYP2C9
6
Q
genetic variation in CYP2C9 reduces
A
warfarin metabolism (increased bleeding risk)
7
Q
genetic variation in the VKORC1 can increase or decrease
A
warfarin sensitivity
