Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

Pharmacology Exam 1 > lecture 3: autonomic pharmacology > Flashcards

lecture 3: autonomic pharmacology Flashcards

1
Q

Parasympathetic NS innervation

A

cranial, sacral nerves

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

sympathetic NS innervation

A

thoracic, lumbar

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

what is an action of the parasympathetic nervous system

A

salivation increased

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

sympathetic NS NT

A

NE, Ep

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

sympathetic receptros

A

alpha and beta adrenergic receptors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

sympathetic action

A

fight or flight actions

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

parasympethic actions

A

rest and digest actions

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

parasymathetic NT

A

ACh

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

parasympathetic receptor

A

mACh, nACh

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

what tone dominates heart rate

A

vagal tone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

ways that a drug can increase the activity of a synapse

A
  1. increase neurotransmitter release into the synapse
  2. reduce reuptake of the neurotransmitter from the synapse
  3. reduce degradation of the neurotransmitter in the synapse
  4. mimic activity of a neurotransmitter at its receptor
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

ways that a drug can decrease the activity of a synapse

A
  1. block a neurotransmitter’s receptor
  2. inhibit synthesis of a neurotransmitter
  3. prevent the release of a NT
  4. prevent packinging in vesicles
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

general drug mechanisms

A
  1. activate M receptors directly
  2. actiivate M receptors indirecrtly by inhibiting AChE
  3. Block M receptors
  4. Inhibit ACh release
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

drugs that enhance PSNS signaling:

A

parasympathomimetics, cholinomimetics

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

drugs that decrease PSNS signaling

A

parasympatholytics, cholinolytics, anticholinergics

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

bethanechol

A

direct-acting muscarininc agonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

bethanechol is resistant to

A

hydrolysis by AChE and very low nicotinic activity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

bethanechol is used for the treatment of

A

non-obstructive GI hypomotility

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

irreversible covalent inhibitors

A

organophosphates

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

organophosphates form a stable bond that does NOT

A

hydrolyze spontaneously

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

pralidoxime (2-PAM)

A

can remove the drug from AChE if given soon after exposure to organophosphates

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

clinical use of anticholinesterases

A

glaucoma
myasthenia gravis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

neostigmine

A

treats muscle weakness by increasing ACh at NMJ

24
Q

insecticide use of anticholinesterases (parathion, malathion)

A

inhibit insect AChE preferentially

25
chemical warfare use of anticholinesterases
organophosphate nerve agents have extremely high potency
26
SLUDGE syndrome happens early after
anticholinesterase exposure
27
SLUDGE stands for
salivation lacrimation urination defecation GI upset emesis
28
autonomic antihcolinesterase effects
nicotonic receptors on autonomic ganglia = effects PSNS AND SNS * Increased HR and blood pressure
29
SLUDGE/DUMBBELLS highlight the symptoms of excess _ stimulation, also called _
cholinergic, cholinergic toxidrome
30
side effectsof anticholinergic drugs
* dry mouth * blurred vision * upset stomach * headache * constipation * dry eyes * dizziness
31
sweating occurs due to the activation of _ receptors
muscarinic
32
drugs that cause anticholinergic toxidrome
antihistamines antidepressants (tricyclics) antipsychotics nightshade plants
33
which drug would increase cholinergic signaling
neostigmine
34
alpha-1 receptor function
increase Ca2+ release
35
alpha-2 receptor function
inhibits NT release
36
beta-1 function
increase HR
37
beta-2 function
relaxation of smooth muscles along respiraotry tract
38
beta-3 function
leads to lipolysis
39
catecholamines
dopamine, NE, Ep
40
NE is released from
sympathetic neurons
41
Ep is released from
adrenal gland when SNS is activated
42
all adrenergic (alpha and beta) receptors are
GPCR
43
sympathomimetic
enhance signaling
44
sympatholytic
decrease signaling
45
which receptor causes vasoconstriction in most tissues
alpha-1
46
which receptor causes vasodilation in skeletal muscle
beta-2
47
which receptor increases HR and contractility
beta-1
48
what receptor dilate/relax bronchial smooth muscle
beta-2
49
which receptor causes mydriasis
alpha-2
50
MAP =
CO x TPR
51
CO =
HR x SV
52
CO =
HR x SV
53
a patient is given a vasodilator drug. what happens to HR
increased
54
what happens to HR when given an alpha agonist
increase baroreceptor increase parasympathetic decrease sympathetic
55
what happens to HR when given a vasodilator (histamine)
decrease baroreceptor decrease parasymp increase sympathetic
56
which class of drugs is associated wiht hypoglycemia
beta blockers

Pharmacology Exam 1 (15 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions