W8_03 Depression Flashcards

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1
Q

fact: depression is the #1 disabling condition in canada

A

good

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2
Q

diagnostic criteria for major depressive episode? (DISIGECAPS)

A
depressed mood
interest loss
sleep changes
impaired function
guilt/worthlessness
energy issues
concentration/cognition issues
appetite/weight loss
psychomotor retardation
suicidality
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3
Q

how is the hypothalamic-pituitary-adrenal axis affected in depression?

A

feedback loop broken;

in dexamethosone suppression test, cortisol continues to be released

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4
Q

how do genetics and environment contribute to major depressive disorder?

A

both cause it synergistically

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5
Q

what does BDNF do?

A

useful for neurogeneration in hippocampus and dendritic spine growth

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6
Q

how does chronic social defeat affect BDNF?

A

downregulates it through methylation of the promoter DNA

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7
Q

how do antidepressants reverse BDNF downregulation?

A

acetylation of histones to make it easier to unravel DNA

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8
Q

fact: exercise increases neurogenesis

A

good

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9
Q

fact: electroconvulsive therapy works

A

good

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