W8_02 Anxiety Flashcards
describe the low road fear pathway
visual/auditory sensation;
thalamus;
amygdala;
hypothalamus
describe the high road fear pathway
visual/auditory sensation; thalamus; visual/auditory cortex; frontal cortex; amygdala; hypothalamus
which receptor is responsible for long term potentiation/depression?
NMDA receptor causes up/downregulation of the AMPA receptor
what is the role of catecholamines in the brain?
carry meta information. can modify the response to other neurotransmitters.
where does serotonin come from in the brain?
raphe nuclei
where does dopamine come from in the brain?
ventral tegmental area
activity in the amygdala is experienced as what emotion?
fear/anxiety
where are fear-context associations stored in the brain?
amygdala in conjunction with the hippocampus
conscious vs unconscious fear?
amygdala gives a general vague sense of fear because it’s subcortical
what are three general types of pathological anxiety?
panic attacks; generalized anxiety disorder; phobias; OCD; PTSD; acute stress disorder
name symptoms of panic
tachycardia; sweating; trembling; shortness of breath; choking; chest pain; nausea; dizziness; fear of going crazy; fear of dying; parasthesia; flushes; derealization; depersonalization
what are three neurotransmitters involved in anxiety?
norepinephrine, serotonin, GABA
where are the structural abnormalities in anxiety?
amygdala, hippocampus, cortex, and their connections
dopamine uses which type of receptor?
GPCR
what’s the timeline of SSRI treatments?
initially exacerbate anxiety by increasing serotonin;
panic attacks reduced over 2-4 weeks;
we believe receptors are downregulated