W6.3 Flashcards
1
Q
Discovery of Complement
A
- Jules Bordet early 1890’s
- Sheep antiserum against Vibrio cholerae was not effective if heated above 56C
- Antibodies are not denatured at 56C
- Must be second component
- Added antibody depleted serum to heated sera- (Restored lytic activity)
- “Complements” activity of antibody
2
Q
Complement
A
3
Q
Synthesis of plasma complement
A
4
Q
Other sources of complement
A
5
Q
Zymogens
A
6
Q
Classical pathway
A
7
Q
Second / Alternative pathway
A
8
Q
Lectin pathway
A
- another antibody-independent means of activating complement proteins.
- Its major constituent, mannose- (or mannan-) binding lectin (MBL), adheres to mannose found mainly in the cell walls or outer coating of bacteria, viruses, yeast, and protozoa.
9
Q
Complement function
A
10
Q
Complement components
A
11
Q
C3 Importance
A
12
Q
Anaphylatoxin
A
13
Q
Main stages of complement activation
A
14
Q
Chemotaxins
A
15
Q
Opsonins
A
humoral factor that acts to coat bacteria so that they become more susceptible to ingestion by phagocytic cells
