W4.2.2 Flashcards
Expansion (T cell response)
Contraction (T cell response)
Maintenance (T cell response)
Recall (T cell response)
Secondary memory (T cell response)
T cell activation (co-stimulation)
Anergy
“result of lack of costimulation
- in absence of good costimulation, T cells do not fully activate
- can either not respond at all and wait for next APC to come along Or cell can become nonresponsive “
chart understanding (Anergy, nothing, clonal, suppression)
immunologic synapse of the CD8+ t cell
”- recognizes peptide in the context of class 1 MHC
- adhesion/costimulatory molecules
- important in intracellular pathogen clearance (viruses) “
mechanisms by which CD8 Tcells can kill
”- perforin/granzyme (perforin makes the hole, granzyme induces apoptosis)
- Fas/Fas ligand (induces apoptosis)
- Apoptotic cells are taken up by APCs “
immunologic synapse of the CD4+ t cell
”- CD4+ HT recognize peptides in the context of class 2 MHC molecules
- Adhesion molecules andd costimulatory molecules provide stability of the complex and important secondary signals
- "”help”” direct the immune response by providing cytokine to other cells
- the cytokines they produce identify them as TH1 or TH2 cells “
TH0
“(immature effector cell) (CD4+)
mature into either TH1/TH2 cells”
TH1
“produce interferon gamma (INF-Y) and tumor necrosis factor-beta (INF-B)
- which protect cell against intracellulr pathogens “
TH2
produce a variety of interleukins (IL-4,5,10.13), essential role of the TH2 cells is to help B cells produce antibody against extracellular pathogens
Treg
“third class of T cells
- CD4, CD25 markers
- important role in suppressing the immune response to self-antigens
- produce interleukins (IL-10) and transforming growth factor (TGFB) -> immune response off”
