W1.2

Question 1

Primary lyphoid organs

Answer 1

sites of production and maturation of immune cells (school)

Question 2

bone marrow

Answer 2

development of all hematopoietic stem cells

Question 3

Lymphoid line

Answer 3

B lymphocyte maturation
Natural Killer (NK) cell maturation
T cell precursors

Question 4

thymus

Answer 4

maturation and selection of T lymphocytes

Question 5

secondary lymphoid organs

Answer 5

potential sites for contact with foreign antigens (Work)
Harbor mature lymphocytes
Where foreign antigens activate lymphocytes
Includes spleen, lymph nodes, mucosal-associated lymphoid tissue

Question 6

spleen

Answer 6

Largest secondary lymphoid organ

Tissue divided into 2 main types (red and white pulp

Question 7

red pulp

Answer 7

function to destroy old RBCs

Question 8

white pulp

Answer 8

Function - contains the lymphoid tissue and drains antigens from blood

Question 9

lymph nodes

Answer 9

Function - filtration; generation of memory B-cells

Central collecting points for lymph fluid from adjacent tissues

Question 10

Lymph fluid

Answer 10

filtrate of the tissue fluids

Question 11

medulla

Answer 11

mostly contains macrophages/DCs (innermost)

Question 12

paracortex

Answer 12

contains mostly T cells and some DCs (middle)

Question 13

cortex

Answer 13

contains B cells organized in follicles (outermost)

Question 14

Primary follicle

Answer 14

contains mature, resting B cells that have not yet been exposed to antigen

Question 15

secondary follicle

Answer 15

consists of antigen-stimulated proliferating B cells (activated B cells form a secondary follicle

Question 16

germinal center

Answer 16

interior of the secondary follicle; contains plasma cells, which actively secrete antibody, and memory cells, their precursors

Question 17

Flow of lymph

Answer 17

Lymph from tissues (contains antigens form infection) → afferent lymphatics → medullary cords → efferent lymphatics
Other : high endothelial venues in the paracortical areas

Question 18

steps of the immun response

Answer 18

Lymph from tissues (contains antigens from infection) comes in via afferent lymphatics
DCs and Macs in the medulla present antigens
EDCs activate T cells that are in the paracortex
Activated T cells give signals to promote cognate B cell proliferation in the follicles

Question 19

MALT

Answer 19

one of the secondary lymphoid organs