w5 - ovulation disorders Flashcards
ovulatory disorders associated oligomenorrhea and amenorrhea. define each
amenorrhea - absent menstruation, either primary or 2ndary
oligomenorrhea - infrequent periods, >35d in between
outline HPO axis (hypothal-pit-ovarian)
hypothalamus secretes GnRH, pit then secretes FSH + LH, causing ovary in follicular phase to secrete estradiol (inhibited in L.phase) and progesteone in L.phase
GnRH stimulates FSH at __ frequency pulses, and LH at __ frequency pulses
FSH = LOW
LH = HIGH
other than stimulating follicuular development, function of FSH
thickens endometrium
other than stimulating corpus luteum development, 2 functions of LH
ovulation
thickens endometrium
LH surge is usually __ before ovulation
36hr
what else peaks prior ovulation, other than LHV
estradiol
progesterone peaks following ovulaton, what produces this
corpus luteum
oestrogen is primarily ecreted by the ___ and adrenal cortex. What else produces it?
Function? (2)
high oestrogen inibits what (2)
ovaries (follicles)
placenta in pregnancy
endometrium thickening
responsible for fertile cervical mucus
FSH + prolactin
progesterone secreted by _ __, why?
what does it inhibit?
function?
effect on temp
corpus luteum
maintains early pregnancy
LH
infertile (thick) cervical mucus
maintain thickness
myometrium relaxation
incr basal body temp
assesing ovulation
regular cycles
confirm by midluteal serum progesterone
hypothalamic pituitary failure will have low levels of __ and __, with __ deficiency, normal __
will it have amenorrhoea or oligomenorrhea?
FSH + LH
oestrogen deficiency
normal prolactin
amenorrhea
7 causes of hypothal-pit failure
stress excessive exercise anorexia brain/pit tumours head trauma kallmans syndrome drugs (opiates, steroids0
management of hypothalamic anovulation
stabilise weight
pulsatile GnRH if hypogonadotrophism hypogonadism
Gonadotrophin (LH +FSH) daily injections
what is required alongside management of hypothalamic anovulation
US