w4 - paediatric diabetes and endo Flashcards

1
Q

Type 1 Diabetes: Presentation

A

WHO:
fasting blood glucose >7.0 mmol/l
random blood glucose >11.0 mmol/l
Classic symptoms:
polyuria; polydipsia; weight loss; general malaise
Diabetic Ketoacidosis
vomiting; abdominal pain; altered consciousness; acidotic breathing
pH < 7.3; urine ketones +++
dehydrated
severe or untreated leads to coma and death

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

as beta cell loss progresses, symptoms of ___ appear

A

hypoglycaemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

__ __ __ is the commonest symptom of new diabetes in children

A

secondary nocturnal enuresis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

what risk involved in treating DKA in children

A

cerebral oedema

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

4Ts of type 1 diabetes in children

A

Toilet
Tired
THirsty
Thinner

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

aims for blood glucose during the day

A

before meals - 4-7
2hrs after 5-9
bedtime 4-7

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

effect of poor control in childhood diabetes

A

social and emotional disruption
sub-optimal physical growth
biophysical changes in microvasc disease (Eyes, kidneys)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

7 early changes of vascular disease in kids type 1 D

A
Microalbuminuria
Cardiovascular autonomic neuropathy
Sensory nerve damage
Retinopathy
Cheiroarthropathy - thickened skin, joint contractures 
Skin vascular changes
Vascular endothelial pathology
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

insulin pump give you continous

A

short acting insulin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

risk for using insulin pump?

A

dka

if it breaks

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

outline insulin pump

A

continuous glucose sensor tells the pump when to give insulin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

most common acquired thyroid disease in toung

A

autoimmune

look for if coeliaac, type 1DM,

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

hypothyroidism in young

A
Often slow progress
Growth “failure”; delayed puberty
Poor general health
Educational difficulties
Goitre
Thyroid function tests: 
High TSH; 
low Free T4 and T3 levels
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

treatment for hypothyroidism

A

Thyroxine replacement for life

Dose related to size of child

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

in children, most common to get hyperthyroidism

A

young girls

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

treatment for hyperthyroidism in young

A
Initial therapy
beta-blockade
Suppressant therapy 
At least first 2 years
carbimazole + / - thyroxine

Permanent cure
radio-iodine
surgery

17
Q

3 hormones from adrenal cortex

A

mineralocorticoids - aldosterone
glucocorticoids - cortisol
adrenal androgens - testosterone

18
Q

how does congenital adreal hyperplasia (females: ambigious genitalia, males: precocious puberty)

A

Only testosterone produced since defiency in enzyme leading to aldosterone and cortisol