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HEMATOLOGY PPT (3rd year) > W3 > Flashcards

W3 Flashcards

1
Q

PROCESS THAT INCLUDES
CELL RENEWAL
CELL PROLIFERATION, DIFFERENTIATION, MATURATION

A

HEMATOPOIESIS

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2
Q

STEM CELL THEORY

ALL BLOOD CELLS ARE DERIVED FROM A SINGLE PROGENITOR STEM CELL

MOST WIDELY ACCEPTED

A

MONOPHYLETIC THEORY

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3
Q

MONOPHYLETIC THEORY

STEM CELL CALLED

A

PLURIPOTENT HEMATOPOIETIC STEM CELL

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4
Q

STEM CELL THEORY

EACH BLOOD CELL LINEAGES DERIVED FROM ITS OWN UNIQUE STEM CELL

A

POLYPHYLETIC THEORY

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5
Q

PRENATAL HEMATOPOIESIS: - PERIOD

CHIEF SITE:

19 DAYS EMBRYOLOGIC DEVELOPMENT

A

MESOBLASTIC PERIOD
YOLK SAC

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6
Q

FOUND IN YOLK SAC OF MESODERMAL CELLS

A

PRIMITIVE ERYTHROBLAST

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7
Q

2ND WEEK OF FETAL LIFE FORMATION OF - IN YOLK SAC

A

BLOOD ISLANDS

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8
Q

9TH WEEK OF FETAL LIFE
DEVELOPMENT OF -

A

PRIMITIVE ERYTHROBLAST

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9
Q

EMRYONIC HEMOGLOBIN

2 ZETA
2 EPSILON

A

GOWER 1

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10
Q

EMRYONIC HEMOGLOBIN

2 ALPHA
2 EPSILON

A

GOWER 2

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11
Q

EMRYONIC HEMOGLOBIN

2 ZETA
2 GAMMA

A

PORTLAND

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12
Q

PRENATAL HEMATOPOIESIS: -PERIOD

BEGINS AT 4-5 GESTATIONAL WEEKS
STARTS ON 2ND MONTH

A

HEPATIC PERIOD

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13
Q

PRENATAL HEMATOPOIESIS: - PERIOD

CHIEF SITE:

3RD MONTH OF FETAL LIFE

A

LIVER
HEPATIC PERIOD

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14
Q

PRENATAL HEMATOPOIESIS: HEPATIC PERIOD

OTHER ORGANS

THYMUS

A

T CELL

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15
Q

PRENATAL HEMATOPOIESIS: HEPATIC PERIOD

OTHER ORGANS

KIDNEYS/SPLEEN

A

B CELL

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16
Q

ERYHTOPOIESIS IN THIS SITE UNTIL NORMAL GESTATION

A

SPLENIC

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17
Q

SPLEEN: BECOMES MINIMAL BY THE 5TH MONTH

A

MYELOPOIESIS

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18
Q

SPLEEN: LIFETIME

A

LYMPHOPOIESIS

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19
Q

FETAL HEMOGLOBIN

2 ALPHA
2 GAMMA

A

HB F

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20
Q

PRENATALL HEMATOPOIESIS: - PERIOD

HEMATOPOIESIS BEGINS TO DEVELOP IN BONE MARROW CAVITY

START 5MOS OF FETAL LIFE

A

MEDULLARY/MYELOID

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21
Q

MYELOID-TO-ERYTHROID RATIO

ADULT LEVEL

21 WEEKS OF GESTATION

A

3:1

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22
Q

BY THE END OF - MONTHS THE BM BECOMES THE PRIMARY SITE OF HEMATOPOIESIS

A

6 MOS

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23
Q

ADULT HEMOGLOBIN

2 ALPHA
2 BETA

A

HB A1

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24
Q

ADULT HEMOGLOBIN

2 ALPHA
2 DELTA

A

HB A2

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25
Q

PRIMITIVE , UNDIFFERENTIATED CELL

A

HEMOCYTOBLAST/ STEM CELLS

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26
Q

TISSUE LOCATED WITHIN THE CAVITIES OF THE CORTICAL BONES

A

BONE MARROW

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27
Q

BONE MARROW CAVITIES CONSIST OF - RESEMBLING A HONEYCOMB

A

TRABECULAR BONE

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28
Q

2 TYPES OF BM:

HEMATOPOIETICALLY ACTIVE MARROW

A

RED MARROW

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29
Q

2 TYPES OF BM:

HEMATOPOIETICALLY INACTIVE MARROW

PRIMARILY COMPOSED OF ADIPOCYTES

A

YELLOW MARROW

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30
Q

BONE MARROW REPRESENT -% TOTAL BODY WEIGHT

A

3.5-6%
1500G

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31
Q

SITE OF B CELL MATURATION

A

BONE MARROW

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32
Q

RATIO OF RED MARROW TO YELLOW MARROW

A

MARROW CELLULARITY

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33
Q

MARROW CELLLULARITY

MARROW HAS 30-70% HSCS

A

NORMOCELLULAR

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34
Q

MARROW CELLLULARITY

MARROW HAS >70% HSCS

A

HYPERCELLULAR/HYPERPLASTIC

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35
Q

MARROW CELLLULARITY

MARROW HAS <30% HSCS

A

HYPOCELLULAR/HYPOPLASTIC

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36
Q

MARROW CELLLULARITY

MARROW HAS FEW OR NO HSCS

A

APLASTIC

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37
Q

FIRST PRECURSON IN EACH CELL LINE

A

BLAST

38
Q

BONE MARROW EXAMINATION: ASPIRATION

ML

A

30-35ML
ASPIRATE 1-3ML

39
Q

BONE MARROW EXAMINATION: ASPIRATION

COMMON SITE FOR APPREHENSIVE PATIENTS

A

ILIAC CREST

40
Q

BONE MARROW EXAMINATION: ASPIRATION

USUAL SITE PUNCTURE IN ADULTS

2ND AND 3RD RIBS

A

STERNUM

41
Q

BONE MARROW EXAMINATION: ASPIRATION

FOR CHILDREN UNDER 2 YEARS OF AGE

A

TIBIA

42
Q

BIOPSY

USES NEEDLE AND CORE SAMPLE

A

NEEDLE BIOPSY

43
Q

BIOPSY

USED TO REMOBE CIRCULAR SECTION

A

TREPHINE

44
Q

BONE MARROW SMEAR

ML OF SPECIMEN
ADDITIVE

A

0.3-0.5ML, EDTA

45
Q

MARROW SMEARS W/O ANTICOAGULANT

  • TYPE: MINUTE DROP OF SPX
A

WEDGE TYPE

46
Q

MARROW SMEARS W/O ANTICOAGULANT

  • TYPE: SEVERAL MARROW PARTICLES
A

PARTICLE SMEAR

47
Q

MARROW SMEARS W/O ANTICOAGULANT

  • TYPE: SQUASHING PARTICLE BETWEEN 2 SLIDES
A

CRUSHED PARTICLE SMEAR

48
Q

MARROW SMEARS W/O ANTICOAGULANT

  • TYPE: IMPRINT OF SPX + ZENKER
A

TOUCH PREP

49
Q

M:E RATIO

6:1
INCREASE

A

INFECTION

50
Q

M:E RATIO

25:1
INCREASE

A

LEUKEMIA

51
Q

M:E RATIO

20:1
INCREASE

A

MYELOID HYPERPLASIA

52
Q

M:E RATIO

3:20
DECREASE

A

MYELOID HYPOPLASIA

53
Q

M:E RATIO

1:20
DECREASE

A

ERYTHROID HYPERPLASIA

54
Q

M:E RATIO

5:1
INCREASE

A

ERYTHOID HYPOPLASIA

55
Q

BONE MARROW DIFFERENTIAL

CELLS COUNTED: -

A

500-1000CELLS

56
Q

MOST MATURE CELL OF PHAGOCYTIC SYSTEM

LARGE 30 UM

IRREGULARLY SHAPED WITH PSEUDOPODS

A

MACROPHAGES
NORMAL

57
Q

12-25UM

BLUE BLACK GRANULES

A

MAST CELLS
NORMAL

58
Q

SYNTHESIZE NEW BONE MATRIX

WATERBUG/ COMET APPEARANCE

A

OSTEOBLASTS
NORMAL

59
Q

INVOLVED IN BONE DEMINERALIZATION AND RESORPTION

100UM

A

OSTEOCLASTS
NORMAL

60
Q

MACROPHAGES IN LIVER CELLS

A

KUPFFER CELLS

61
Q

RETICULOENDOTHELIAL ORGAN

FUNCTION: LYMPHOPOIESIS AND PHAGOCYTOSIS

A

SPLEEN

62
Q

SITE OF EXTRAMEDULLARY HEMATOPOIESIS

STORES 30% OF PLATELETS (1/3 OF PLATELETS)

A

SPLEEN

63
Q

SPLEEN PULP

CONTAINS LYMPHOID TISSUE

A

WHITE PULP

64
Q

SPLEEN: WHITE PULP

COTAINS MAINLY T CELLS

A

PALS
PERIARTERIOLAR LYMPHOID SHEATHS

65
Q

SPLEEN: WHITE PULP

CONTAINS NAIVE B CELLS

A

PRIMARY FOLLICLES

66
Q

SPLEEN: WHITE PULP

CONTAINS DENDRITIC CELLS

A

MARGINAL ZONE

67
Q

SPLEEN PULP

CONTAINS SPECIALIZED MACROPHAGES FOR REMOBAL OF SENESCENT RBCS

A

RED PULP

68
Q

SPLEEN: RED PULP

PROCESS OF DESTROYING SENESCENT RBCS

A

CULLING

69
Q

SPLEEN: RED PULP

PROCESS OF REMOVING RBC INCLUSION

A

PITTING

70
Q

SPLEEN: RED PULP

REMOBAL OF MATURE RBC, DEGRADATION OF CELL ORGANELLES

A

CULLING

71
Q

ACTS AS A FILTER TO REMOVE FOREIGN BLOOD CONTAMINANTS

FOR BODYS INFECTION DEFENSE

A

LYMPH NODES

72
Q

IMMATURE LYMPHOCYTES MATURE IN THE -

A

LYMPH NODES

73
Q

LAYERS OF LYMPH NODES

CONTAINS MACROPHAGE, FOLLICULAR DENDRITIC CELLS

NAIVE OR RESTING B CELL

A

PRIMARY FOLLICLE-CORTEX

74
Q

LAYERS OF LYMPH NODES

CONTAINS PROLIFERATING B CELLS AND PLASMA CELLLS

A

SECONDARY FOLLICLES-CORTEX

75
Q

LAYERS OF LYMPH NODES

CONTAINS MAINLY T CELLS

A

PARACORTEX

76
Q

LAYERS OF LYMPH NODES

CONTAINS T CELLS, B CELLS, PLASMA CELLS, MACROPHAGES

A

MEDULLA

77
Q

RESPONSIBLE FOR NORMAL DEVELOPMENT OF LYMPHOCYTES

NECK AREA

A

THYMUS GLAND

78
Q

FOUND IN BIRDS ANALOGOUS TISSUE IN MAN

FOR NORMAL ANTIBODY PRODUCTION

A

BURSA FABRICUS

79
Q

MAJOR COMPARTMENT/ CELL TYPES

PRESENT IN THE FIRST FEW HOURS AFTER FERTILIZATION

MOST VERSATILE CAN DEVELOP IN ANY HUMAN CELL TYPE

EMBRYO TO FETUS

A

TOTIPOTENTIAL STEM CELLS

80
Q

MAJOR COMPARTMENT/ CELL TYPES

PRESENT SEVERAL DAYS AFTER FERTILIZATION

CANNOT DEVELOP INTO FETUS

A

PLURIPOTENTIAL STEM CELLS

81
Q

MAJOR COMPARTMENT/ CELL TYPES

FROM PLURIPOTENT STEM CELLS
LIMITED TO SPECIFIC TYPES

A

MULTLIPOTENTIAL STEM CELLS

82
Q

CAN DIFFERENTIATE INTO ANY CELL LINE

A

STEM CELLS

83
Q

STEM CELLS

MULTIPOTENTIAL STEM CELLS -> NON-LYMPHOCYTES

A

CFU-S

84
Q

STEM CELLS

SECONDARY MULTIPOTENTIAL STEM CELLS ->LYMPHOCYTES

A

CFU-L

85
Q

CAN DIFFERENTIATE INTO ONLY ONE CELL LINE

A

PROGENITOR CELLS

86
Q

3RD MARROW COMPARTMENT= BLAST FORM

A

PRECURSOR CELLS

87
Q

STIMULATES ERYTHROID CFU CELLS AND PROERYTHROBLASTS

A

EPO

88
Q

STIMULATES MEGAKARYOCYTE CFU CELLS

A

TPO

89
Q

STIMULATES GRANULOCYTE-MACROPHAGE CFU CELLS

A

G-CDF

90
Q

STIMULATES B AND T CELL FORMATION

WITH G-CSG AND GM-CSF

A

INTERLEUKINS

91
Q

GROWTH FACTOR

FROM PERITUBULAR CELLS OF THE KIDNEYS

A

ERYTHROPOIETIN

92
Q

GROWTH FACTOR

FROM ACTIVATED T LYMPOHCYTES

TARGET: EO, MONO

A

IL-3

HEMATOLOGY PPT (3rd year) (5 decks)

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