W25/L7 Flashcards
1
Q
What is the enzyme that interconverts cortisol and cortisone?
A
11beta-HSD
2
Q
Which form of 11b-HSD is found in the kidney? What does it do?
A
11beta-HSD 2 in the kidney converts active cortisol to inactive cortisone
3
Q
Why is there 11b-HSD 2 in the kidney?
A
Cortisol is an agonist at the aldosterone receptor
4
Q
Which form of 11b-HSD is found in the liver? What does it do?
A
11b-HSD 1 in the liver converst inactive cortisone to active cortisol
5
Q
What happens in the adrenals as a result of prolonged GCC treatment?
A
Adrenal suppression:
Downregulation of CRH/ACTH
Atrophy of the adrenal glands
6
Q
What can occur if systemic GCC t’ment is suddenly withdrawn?
A
Iatrogenic hypercortisolism due the adrenal suppression.
