W25/L5

Question 1

Which hormones are made in the glomerulosa of the adrenal cortex?

Answer 1

Mineralocorticoids

Question 2

Which hormones are made in the fasiculata of the adrenal cortex?

Answer 2

Glucocorticoids

and some androgens

Question 3

Which hormones are made in the reticularis of the adrenal cortex

Answer 3

Sex steroids/androgesn

and some cortisol

Question 4

Hydrocortisone is the exact same as:

Answer 4

Cortisol

Question 5

What is cortisone?

Answer 5

A relatively inactive metabolite of cortisol

Question 6

What is the common precursor for all the adrenal hormones?

Answer 6

Cholesterol

Question 7

What do GCCs do in the liver?

Answer 7

Stimulate gluconeogenesis

Question 8

What do GCCs do in the muscle?

Answer 8

Stimulate mobilisation of amino acids

Question 9

What do GCCs do in the adipose tissue?

Answer 9

Stimulate lipolysis

Question 10

How do GCCs cause hypertension?

Answer 10

Binding of the MCC receptor, causing aldosterone-like effects: sodium and water retention.

Question 11

What’s Cushing’s disease?

Answer 11

An ACTH-secreting pituitary adenoma

Question 12

What are the two forms of hypercortisolism?

Answer 12

ACTH dependent
ACTH independent ("Cushing's syndrome")

Question 13

What are some ACTH dependent hypocortisolisms?

Answer 13

Cushing’s disease

Ectopic ACTH syndrome

Question 14

What’s a common source of ectopic ACTH syndromes?

Answer 14

Lung tumours

Question 15

What things regulate aldosterone synthesis?

Answer 15

[K] in ECF

AngII

Question 16

Are hydrocortisone and cortisone the same?

Answer 16

No!

Hydrocortisone = cortisol
Cortisone is the ~inactive metabolite

Question 17

What the the stress hormones secreted by the adrenal medulla?

Answer 17

NA & adrenaline