W25/L4

Question 1

What’s the macroscopic structure of the adrenal gland?

Answer 1

Outer cortex which secretes steroids

Inner medulla which is modified sympathetic ganglion & secretes catecholamines

Question 2

In what was is the adrenal gland similar to the pituitary?

Answer 2

Two anatomically joined glands with different origins and function - one is modified neuronal, and one is true endocrine

Question 3

What is primarily secreted by the zona reticularis?

Answer 3

Sex hormones

Question 4

What is primarily secreted by the zona fasciculata?

Answer 4

GCCs

Question 5

What is secreted by the zona glomerulosa?

Answer 5

Aldosterone

Question 6

Which layer of the adrenal cortex primarily secretes sex hormones?

Answer 6

Zona reticularis

Question 7

Which layer of the adrenal cortex primarily secretes GCC’s

Answer 7

Zona fasciculata

Question 8

Which layer of the adrenal cortex secretes aldosterone?

Answer 8

Zona glomerulosa

Question 9

From outer-inner, what are the laters of the adrenal cortex?

Answer 9

Glomerulosa
Fasciculata
Reticularis

Question 10

What is the control of cortisol release?

Answer 10

CRH from the hypothalamus
ACTH from the AP
Cortisol from the ZF of the adrenal cortex

Question 11

From what protein is ACHT derived?

Answer 11

POMC

Question 12

What can happen to ACTH in non pituitary tissues?

Answer 12

Cleavage to a-MSH

Question 13

What are the roles of a-MSH?

Answer 13

Melanin synthesis
Immune response
Decreased food intake

Question 14

How can liver diseases affect cortisol levels?

Answer 14

Cortisol binding protein is synthesised in the liver.

Question 15

What is Addison’s disease?

Answer 15

AI destruction of the adrenal cortex