W20/L5 Flashcards
1
Q
What are some disadvantages of barbituates?
A
Highly toxic - low TI
High addictive
2
Q
What’s the MoA of benzo’s?
A
They’re allosteric modulators of the GABA-A receptor, which increase its affinity for GABA.
3
Q
What’s an example of a benzo?
A
Diazepam
4
Q
What are some adverse effects of benzo’s?
A
Drowsiness
Confusion
Impaired coordination
5
Q
What are some disadvantages of benzo’s?
A
Dependency & withdrawal symptoms
Long-lasting hangover effects
Interaction with alcohol, antihistamines & barbituates
6
Q
What is the MoA of barbituates?
A
They’re allosteric modulated of the GABA-A receptor that increase the duration of ion channel opening
They’re also blockers of the glutamate receptor (AMPA)
7
Q
Benzo’s vs barbituates - which is more toxic?
A
Barbituates
