w19 inflammation & tissue repair Flashcards
Inflammation is a response of ……….. …….. to …..
vascularised tissue to injury
what is the nomenclature of inflamm.
tisssue name 7 itis - carditis , arthiritis
Describe & Name the 4 cardinal signs of inflammation
Rubor (redness): due to dilatation of small blood
vessels
* Tumor (swelling): due to accumulation of fluid
* Calor (heat): due to ^^ b. flow
* Dolor (pain): due to the stretching and distortion
of tissues and due to bradykinin
(described by Celsus 1st. Century
AD)
* Functio laesa (loss of function):
(added by R. Virchow)
Can inflammation be harmful or beneficial
both
When is inflammation beneficial
● Inflammation dilute, destroy or neutralize the
offending agents
- e.g. destruction of invading microorganisms and the
walling-off of an abscess cavity, thus prevent spread of infection
- follwwed by repair
When is inflamm. harmful
Both the initial inflammatory reaction and the
subsequent healing process can potentially cause harm in delicate tissues such as brain tissue
Name some causes of inflamm
Causes
* Infection
* Trauma
* Necrosis
* Immune-mediated
* Toxin
* Chemical
describe steps of inflammation
1) Vasodilation and permeability of blood
vessels increased
2) Phagocyte migration and phagocytosis
3) Tissue healing and repair
Inflammation
chronic vs acute inflamm
acute (days-wks) chronic (mnths-yrs , persistant)
acute inflam
- Shot duration (hours to days)
- Flush, Flare & Wheal
- Acute inflam. Cells
– Neutrophils - Vascular damage
- More exudation
- Little or no fibrosis
describe chronic inflammation
- Longer duration (days to
years) - Chronic inflam. cells –
Lymphocytes, macrophage
plasma cells - Neo-vascularisation
(angiogenesis) - Less exudation
- Prominent fibrosis
Name some diffs bw chronic and acute
..
finish last slides
