Von Willebrand's Disease

Question 1

What is VWD?

Answer 1

Von Willebrand disease (VWD), the most common inherited bleeding disorder, is due to either a quantitative or qualitative abnormality of von Willebrand factor (VWF)

Question 2

What are the Risk Factors of VWD?

Answer 2

> FHx

> Consanguinous Relationships

Question 3

What are the signs and symptoms of VWD?

Answer 3

> High bleeding (minor wound, post operative, menorrhagia)

> FHx of bleeding

> Epistaxis

> Blood transfusions

> Haemarthrosis

> Haematuria

> CNS bleeds

Question 4

What is the epidemiology of VWD?

Answer 4

VWD is the most common inherited bleeding disorder, affecting 66 to 100 people per million of the general population, if patient referral for clinical manifestations is used as the basis for diagnosis

Question 5

What investigations should you do for VWD?

Answer 5

> PT (normal) > aPTT (prolonged) > FBC (normal except 2B low plt) > VWF antigen (low) > VWF function assay (low) > Factor 8 activity (low)

Question 6

What are the types of VWD?

Answer 6