TTP Flashcards

1
Q

What is TTP?

A

Thrombotic thrombocytopenic purpura (TTP) is a clinical syndrome characterised by microangiopathic haemolytic anaemia and thrombocytopenic purpura

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2
Q

What are the Risk Factors of TTP?

A
> Black
> Female
> Obesity
> Pregnancy
> Cancer therapies
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3
Q

What are the signs and symptoms of TTP?

A
> Severe neuro problems
> fever
> digestive problems
> weakness
> blood symptoms (purpura, ecchymosis, menorrhagia)
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4
Q

What is the epidemiology of TTP?

A

2.2 cases per million per year in the UK

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5
Q

What investigations should you do for TTP?

A
> FBC (low plt/ Hb)
> haptoglobin (low)
> peripheral smear (schistocytes)
> reticulocyte count (high)
> urinalysis (protein)
> urea and creatinine (high)
> direct Coombs' test (neg)
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