TTP

Question 1

What is TTP?

Answer 1

Thrombotic thrombocytopenic purpura (TTP) is a clinical syndrome characterised by microangiopathic haemolytic anaemia and thrombocytopenic purpura

Question 2

What are the Risk Factors of TTP?

Answer 2

> Black
> Female
> Obesity
> Pregnancy
> Cancer therapies

Question 3

What are the signs and symptoms of TTP?

Answer 3

> Severe neuro problems
> fever
> digestive problems
> weakness
> blood symptoms (purpura, ecchymosis, menorrhagia)

Question 4

What is the epidemiology of TTP?

Answer 4

2.2 cases per million per year in the UK

Question 5

What investigations should you do for TTP?

Answer 5

> FBC (low plt/ Hb)
> haptoglobin (low)
> peripheral smear (schistocytes)
> reticulocyte count (high)
> urinalysis (protein)
> urea and creatinine (high)
> direct Coombs' test (neg)