TTP Flashcards
1
Q
What is TTP?
A
Thrombotic thrombocytopenic purpura (TTP) is a clinical syndrome characterised by microangiopathic haemolytic anaemia and thrombocytopenic purpura
2
Q
What are the Risk Factors of TTP?
A
> Black > Female > Obesity > Pregnancy > Cancer therapies
3
Q
What are the signs and symptoms of TTP?
A
> Severe neuro problems > fever > digestive problems > weakness > blood symptoms (purpura, ecchymosis, menorrhagia)
4
Q
What is the epidemiology of TTP?
A
2.2 cases per million per year in the UK
5
Q
What investigations should you do for TTP?
A
> FBC (low plt/ Hb) > haptoglobin (low) > peripheral smear (schistocytes) > reticulocyte count (high) > urinalysis (protein) > urea and creatinine (high) > direct Coombs' test (neg)