Volatiles

Question 1

What is Halothane known for? What year?

Answer 1

Hepatitis and bronchodilation
1956

Question 1

What is dangerous about cyclopropane? What year?

Answer 1

Very explosive
1934

Question 2

What year did Isoflurane come out? What is its MAC? What was great about it? What was not so great about it?

Answer 2

1981
1.13%
Decreased n/v, no exploding, quick onset, very stable/steady, less CV issues. Volatile choice for hearts in the 90s. Cheap
Changing doses can cause fluctuations in HR & BP - had to turn it on and leave it alone

Question 3

What is the most rapid uptake & distributed volatile? What is its MAC? What year did it come out? What was it used for?

Answer 3

Desflurane
MAC 6.6%
1992
Great for quick procedures (minutes) - tubes, tonsils, D&C, knee scopes. Adjustable. Required high volume to achieve anesthetic b/c it has a high MAC

Question 4

What did Edmund Egar do? What does MAC stand for? What volatile did he use for his research?

Answer 4

End-tidal concentration correlated to movement study (MAC)
Minimal alveolar concentration - used for dosing volatiles
Desflurane

Question 5

What volatile is intermediate, between isoflurane and desoflurane? What year did it come out? What is its MAC?

Answer 5

Sevoflurane
1995
MAC 2%