Exam 2

Question 1

What are considered Opioid Agonist-Antagonists?

Answer 1

Pentazocine
Butorphanol
Nalbuphine
Buprenorphine
Bremazocine
Dezocine

Question 2

What receptors bind to an Opioid Agonist-Antagonist?

Answer 2

Mu, Kappa, Delta
Acts as partial agonist or competitive antagonist on the Mu receptor
Acts as a partial agonist on the Kappa and Delta receptors

Question 3

Thiopental Dose

Answer 3

4mg/kg IV

Question 4

Methohexital dose and PR dose

Answer 4

1.5mg/kg
20-30mg/kg

Question 5

Propofol Dose for induction, conscious sedation, and maintenance?

Answer 5

Induction: 1.5-2.5mg/kg IV
Sedation: 25-100mcg/kg/min
Maintenance: 100-300mcg/kg/min

Question 6

Elimination 1/2 time of propofol, etomidate, ketamine

Answer 6

Propofol: 0.5-1.5 hrs
Etomidate: 2-5 hrs
Ketamine: 2-3 hrs

Question 7

Vd for propofol, etomidate, ketamine

Answer 7

Propofol: 3.5-4.5 L/kg
Etomidate: 2.2-4.5 L/kg
Ketamine: 2.5-5.5 L/kg

Question 8

Clearance for propofol, etomidate, ketamine

Answer 8

Propofol: 30-60 ml/kg/min
Etomidate: 10-20 ml/kg/min
Ketamine: 16-18 ml/kg/min

Question 9

Propofol’s, Etomidate’s, and Ketamine’s effect on HR and BP

Answer 9

Propofol: Decreases
Etomidate: no change
Ketamine: Increases

Question 10

Etomidate dos

Answer 10

0.3mg/kg IV

Question 11

Ketamine (PCP) dose for induction, maintenance, subanesthetic (analgesic dose), post-op sedation, and neuraxial analgesia

Answer 11

Induction: 0.5-1.5mg/kg IV
Maintenance: 0.2-0.5mg/kg IV or 4-8mg/kg IM
Subanesthetic: 0.2-0.5mg/kg IV
PostOp: 1-2mg/kg/hr (also for ped heart surgery)
Neuraxial: 30mg in Epidural and 5-50mg in 3mLs of saline intrathecal/spinal/subarachnoid

Question 12

Cocktail for CAD

Answer 12

Diazepam 0.5mg/kg IV
Ketamine 0.5mg/kg IV
Continuous ketamine infusion 15-30mcg/kg/min IV

Question 13

What is Ketafol

Answer 13

50mg of ketamine in 50mLs of Propofol

Question 14

What are the excitatory impulses

Answer 14

glutamate, calcitonin neuropeptide Y, aspartate, substance P

Question 15

What are the inhibitory impulses

Answer 15

GABA, glycine, enkephalin, norepinephrine, dopamine

Question 16

What are the doses for Morphine

Answer 16

Induction: 1-10mg IV
PostOp 5-20mg

Question 17

Demerol dose for post-op shivering

Answer 17

12.5mg

Question 18

Fentanyl dose for induction, adjunct, surgical anesthesia (SOLO), intrathecal, transmucosal, and transdermal

Answer 18

Induction: 1.5-3mcg/kg IV
Adjunct: 2-20mcg/kg iv
Surgical Anesthesia: 50-150mcg/kg IV
Intrathecal: 25mcg w/ LA
Transmucosal: 5-20mcg/kg 2-8yrs old give 15-20mcg/kg PO 45 mins prior
Transdermal: 25-100mcg (18hrs of delivery)

Question 19

Doses for Sufentanil

Answer 19

Induction: 18.9mcg/kg IV
Analgesia: 0.1-0.4mcg/kg IV
IntraOp: 0.3-1mcg/kg IV
Infusion: 0.5-1mcg/kg/hr IV

Question 20

Doses for Alfentanil

Answer 20

Induction w/ laryngoscopy: 15-30mcg/kg IV
Induction alone: 150-300mcg/kg IV
Maintenance: 25-250mcg/kg/hr w/ inhales

Question 21

Doses for Remifentanil

Answer 21

Induction: 0.5-1mcg/kg IV over 30-60 secs
Maintenance: 0.25-1mcg/kg IV or 0.005-2mcg/kg/min

Question 22

Codeine dose for cough and pain

Answer 22

Cough: 15mg
Pain: 60-120mgs

Question 23

Pentazocine MCPD

Answer 23

10-30mg IV or 50mg PO; 20-30mg IM similar sedation & depression of ventilation to 10mg Morphine

Question 24

Doses for opioids antagonist

Answer 24

1-4mcg/kg IV
5mcg/ IV continuous drip
>1mg/kg IV Shock
Epidural S/E: 0.25mcg/kg/hr IV

Question 25

Morphine PCA dose

Answer 25

Base Rate: 0-2mg/h
Bolus: 1-2mg
Bolus Interval: 6-10min

Question 26

Hydromorphone PCA

Answer 26

Basal Rate: 0.04mg/h
Bolus Dose: 0.2-0.4mg
Bolus Interval: 6-10 min