VIVA Flashcards

1
Q

PV Bleed + abdominal pain —- approach + Tx of ectopic pregnancy

A

approach

impression —- DDx
ectopic pregnancy
miscarriage
menorrhagia
acute abdomen
gynae malignancy

resus ABCDEs

focused Hx

symptoms:
abdo pain — SOCRATES
PV bleed — vol, assoc symptoms
r/o symptoms of ectopic rupture: sudden onset lower abdo pain/shoulder tip pain, rectal pressure, fainting, PV bleeding

gynae
last menstrual period
usually get menorrhagia? — whats diff this time

kardex
anticoagulants
COCP — compliance?

physical exam:

signs of rupture:
vitals: hypotension
abdo distension
rebound tenderness

bimanual exam: cervical motion or adnexal tenderness
Ensure bleeding is truly PV

Ix
bedside: beta hCG
bloods: FBC, U&E, grp & hold 2 units, coag profile
abdo or transvaginal US — findings:
homogenous adnexal mass separate from ovary
empty extra-uterine gestational sac
foetal pole
free fluid
pseudosac
diagnostic laparoscopy

Tx of ectopic pregnancy

conservative = rare
impt to safety net for red flags — severe abdo pain, PV bleeding
monitor until hCG <15

medical Tx = methotrexate 50 mg/m2 single IM dose
indication: small + low hCG + no complications
monitor hCG day 4 & 7 — until hCG <15
if needed = give 2nd dose

surgical Tx = laparoscopy w salpingectomy or salpingostomy
post-op = give anti-D

counsel patient

ToDo:
stop smoking
attend EPAU (early pregnancy assessment unit) at 6-8 wks in future pregnancies — to confirm intrauterine pregnancy

prognosis
7-10% recurrence rate
65% will achieve successful pregnancy within 18 months of an ectopic

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2
Q

female + reproductive age + acute LIF pain — approach + Tx of ovarian cyst

A

approach

impression
acute abdomen — appendicitis, diverticulitis, bowel obstruction
ectopic pregnancy
ovarian cyst +/- rupture

resus ABCDEs

focused Hx

symptoms:
pain — SOCRATES
precipitant: physical activity, sexual intercourse
symptoms of rupture
pre-rupture = intermittent unilateral abdo pain
post-rupture = severe unilateral abdo pain

gynae
last menstrual period
sexually active

DDx cause

physical exam

signs of rupture
vitals — hypotension
abdo distension
rebound tenderness

bimanual exam: cervical motion or adnexal tenderness

Ix
bedside: beta hCG
bloods: FBC, U&E, coag profile, grp & hold 2 units, CA125
trans-abdominal or transvaginal US

calculate RMI risk of malignancy index

Tx of ovarian cyst

no rupture = conservative — analgesia, antiemetic

rupture = laparoscopy — cystectomy or salpingo-oophorectomy

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3
Q

28 wks gestation pregnant woman + headache + blurred vision + epigastric pain —- approach + Tx of severe pre-eclampsia vs eclampsia

A

approach

impression
severe pre-eclampsia or imminent eclampsia
migraine
cortical venous thrombosis

resus ABCDEs

focused Hx

symptoms — signs of imminent eclampsia
headache
aura
visual disturbance
epigastric pain
hyperreflexia/clonus
vomiting

DDx
migraines
pre-eclampsia
official diagnosed
how well controlled
usual BP + when was last visit
cortical venous thrombosis

kardex
meds for pre-eclampsia

physical exam

maternal
neuro — hyperreflexia/clonus

foetal
wellbeing – HR, movements

Ix
vitals – BP >140/90
bloods: U&E
r/o HELLP — FBC, LFTs, LDH
US foetus
CTG

Tx

severe pre-eclampsia:
admit to HDU
lower HTN carefully — IV labetalol + hydralazine
fluid restriction
LMWH
monitor regularly: vitals, physical exam, U/O, continuous CTG
if still uncontrolled = primary prevention of eclampsia: MgSO4 4g loading dose + 1g per hr IV infusion
continue up to 24 hrs post delivery
if 24-34 wks gestation = dexamethasone
arrange for delivery

eclampsia:
resus ABCDEs
suction any foam or secretions
dont attempt to insert airway when actively seizing
position: left lateral
seizure control + secondary prevention = 4g loading dose + 2g per hr IV infusion
NOT diazepam or phenytoin!!!
continue for up to 24 hrs post delivery
HTN: IV labetalol + hydralazine
fluid restriction
LMWH
stabilise for delivery
if 24-34 wks gestation = dexamethasone

post-delivery:
monitor BP acutely + for the next 2 months (shld normalise)
monitor for seizures – esp 1st 24 hrs
continue antihypertensives
counsel for future pregnancies
ToDo
stop smoking
target CVS risk factors
daily low dose 75mg aspirin OD from 12 wks gestation

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4
Q

PPH post partum haemorrhage — approach + Tx

A

approach

impression = PPH

resus ABCDEs + IMEWS
insert 2 wide bore 14-16G IV Cannulas
500ml warmed normal saline over 10-15 mins
activate massive transfusion protocol if needed
insert foley catheter to decompress bladder

Call for senior help

focused Hx

symptoms
quantity of blood loss
time of delivery —- ie pri vs sec
pri = within 24 hrs of delivery
sec = 24 hrs to 6 wks
Has placenta been delivered

DDx cause — 4 Ts
tone
tissue
trauma
thrombus

physical exam

Ix
bloods: FBC, U&E, Coag profile, GXM 4 units

Tx

prevention
oxytocin during the 3rd stage of labour
careful delivery of placenta

PPH triangle — scribe
monitoring — vitals, ECG, U/O
resuscitation team
Tx — acc to cause

Tx of uterine atony

medical
ergometrine
prostaglandin F2 alpha
misoprostol
tranexamic acid
oxytocin

surgical — if medical fails
bimanual massage
balloon tamponade
B lynch suture
uterine A ligation
hysterectomy

Tx of retained products of conception
if placenta has separated from uterine wall = controlled cord traction
if placenta hasnt separated from uterine wall = manual removal
if small section or lobe of placenta left behind = ERPC evacuation of retained products of conception

post-acute phase
debrief family & team
monitor for complications

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4
Q

pregnant woman + IMEWS >2 — ?obstetric sepsis — approach + Tx

A

approach
impression = obstetric sepsis

resus ABCDEs

call for senior help

focused Hx

symptoms:
tender abdomen
respi symptoms: SOB, chest pain

pregnancy:
preterm or at term
any recent interventions — cerclage, amniocentesis

physical exam:
abdo: tenderness
vaginal: offensive vaginal discharge
respi: crepitations

Ix
bedside: urine dipstick
bloods: FBC, U&E, C&S
if ? UTI = MSU
if ?PID = high vaginal swab + cervical swab + 1st void urine

sepsis 6

take 3
bloods
blood C&S
insert urinary catheter — monitor U/O

give 3
supplementary O2
IV fluids
empirical Abx: gentamicin (1 dose immediately) + cefotaxime + metronidazole

+1 = CTG — assess foetal wellbeing

monitor patient
if severe = xfer to HDU/ICU + change empirical Abx
monitor for signs of maternal end organ dysfunction
If CTG non-reassuring = consider antenatal steriods + emergency caesarean section

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5
Q

maternal cardiac arrest —- approach + Tx

A

impression = maternal cardiac arrest

check for response

no response = call for help — crash cart, AED, call for obstetric resuscitation team, if >22 wks = call neonatal team

commence CPR
position: wedge under spine or manual left displacement of uterus
CPR compressions higher on sternum

once help arrives
connect AED machine to patient
insert 2 wide bore IV cannulas
supplementary O2 (15L O2 via non-rebreather mask) + head tilt & chin lift —- consider intubation if experienced anaesthetist present

if shockable rhythm (ventricular fibrillation or pulseless ventricular tachycardia) = provide shock
ensure foetal monitoring detached prior to shocking

give adrenaline 1mg 1:10000 ASAP — rhythm check every 2 mins, adrenaline every 4 mins

after 4 mins of effective attempt to resus + mother still unresponsive = emergency delivery or perimortem caesarean section

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6
Q

sick child — approach + Tx

A

impression = sick child
impt to detect red flags — children compensate well v.initially but decompensate v.rapidly

resus — paediatric ABCDES
circulation — cap refill time of sternum

focused Hx

symptoms

DDx cause

physical exam = paediatric assessment triangle

general appearance:
abnormal tone
reduced interactiveness
reduced consolability
abnormal look or gaze
abnormal speech or cry

work of breathing:
abnormal sounds
abnormal position
retraction
nasal flaring
apnoea or gasping

circulation to skin:
pallor
mottling
cyanosis

impt to r/o pre-terminal signs — ECHOS
E: exhaustion
C: central cyanosis
H: hypotension
O: O2 sat <85% on RA
S: silent chest

also consult the NICE guidelines traffic light system — ensure no serious illness present

if need be = consult WETFLAG algorithm for emergency calculations in paediatrics

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7
Q

acute onset chest pain + palpitations —- approach + Tx of afib

A

approach

impression
arrhythmia
MI
PE

resus ABCDEs
check vitals, GCS, blood sugar levels

focused Hx

HOPC:
palpitations
syncope/pre-syncope
reduced exercise capacity
SOB
chest pain
peripheral oedema, orthopnoea, PND

DDx causes — ARITHMETIC
A: alcogol
R: rheumatic heart disease
I: ischaemia — MI
T: thyrotoxicosis
H: HTN
M: mitral valve disease
E: endocarditis
T: toxins — cocaine, steroids
I: infections
C: cardiomyopathy

kardex
anticoagulation

notes: check old ECGs for comparison

physical exam
irregularly irregular pulse or no palpable pulse
signs of HF: raised JVP, parasternal heave, peripheral cyanosis
murmurs

Ix
bedside = ECG —- findings
irregularly irregular pulse
absent p waves
narrow QRS complex
absent isoelectric baseline
variable ventricular rate

bloods: FBC, U&E, d-dimers, troponins, TFTs, BNP
imaging: CXR, ECHO

Tx of afib

conservative Tx
stop smoking
reduced alcohol intake
lifestyle: increased exercise, reduced fat & salt in diet, maintain healthy BMI
strict glycaemic control if DM

acute Tx

rhythm control
if unstable = emergent DC conversion

if stable
afib onset <48 hrs = give heparin then cardiovert — either DC or medical cardioversion
afib onset >48 hrs = give anticoagulation for at least 3 wks before cardioverting
or: do TOE to r/o left atrial appendage thrombus — then heparin and cardiovert

medical cardioversion — acc to amt of structural damage to heart
mild: oral flecainide
moderate: IV flecainide
severe: IV amiodarone

rate control — until successful cardioversion
beta blockers —- initially metoprolol, then longer acting bisoprolol/nebivolol
non-dihydropyridine CCB — diltiazem or verapamil

anticoagulation
if new onset <48 hrs + cardioverted = acc to CHA2DS2Vasc
if new onset >48 hrs = 3 wks before cardioversion + at least 4 wks post cardioversion
drug choice
non-valvular afib = DOAC
valvular afib = warfarin

long term
CVS risk factors
hyperlipidaemia
CHA2DS2-Vasc score

criteria
CHF — 1
HTN – 1
Age 65-74 — 1; >75 y/o — 2
DM – 1
Sex female — 1
stroke/TIA — 2
Vascular disease —- 1

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8
Q

anaphylaxis — definition + approach & Tx

A

anaphylaxis: sudden, rapidly progressive, systemic type I hypersensitivity reaction — that is potentially life-threatening due to airway compromise & hypotension

approach & Tx

resus ABCDEs
airway = early endotracheal intubation
breathing = 15L O2 via non-rebreather mask
if respi distress persists + adrenaline has been administered = 5mg salbutamol nebulised
circulation = 500ml bolus normal saline if hypotensive

assess severity
mild: urticaria +/- angioedema (swelling around face, etc)
moderate: above + bronchospasm
severe: above + respi or haemodynamic compromise

adrenaline 0.5mg 1:1000 —- ie 0.5ml
inject into anterolateral aspect of the middle 1/3 of thigh
repeat dose every 5-15 mins if life-threatening symptoms remain
after 2 IM doses = IV adrenaline attempted by specialist

+/- antihistamines (chlorphenamine 10mg IV)

+/- steroids (125mg IV methylprednisolone)
only if severe

monitor for 6-12 hrs post-onset
bi-phasic rxns can occur in up to 20%

amend allergies box in kardex

follow up
detailed Hx of allergies & triggers
refer for allergen testing
safety net for discharge
adrenaline autoinjector
emergency action plan
avoid triggers

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9
Q

ED: fever + photophobia + neck stiffness — approach + Tx of meningitis

A

approach
impression = CNS infection (meningitis, encephalitis)
or migraine

resus ABCDEs

focused hx + potentially collateral Hx

symptoms:
classic triad of meningitis = fever + neck stiffness + AMS
signs of meningism = photophobia
N&V
focal neuro deficits
seizures
reduced GCS

close contacts — similar symptoms

vaccinations — esp Hib, Men B/C

physical exam
kernig’s sign
brudzinski’s sign
focal neuro signs

Ix
vitals
bloods: FBC, CRP, coag profile, U&E, glucose, C&S, viral PCR
LP — ensure no raised ICP + no decreased in consciousness!!
if not = MUST CT brain before LP
+/- CT Brain

Tx

empirical Abx —- acc to local hospital guidelines
duration: at least 7 days
VACA
vancomycin
+/- ampicillin (if ?listeria)
cefotaxime/ceftriaxone
+/- aciclovir (if ?HSV)
if GP setting = benzylpenicillin before xfer to hospital

IV dexamethasone BEFORE or w 1st dose of Abx
CONSULT SENIOR
benefit: reduced risk of neuro complications
withhold if: septic shock, meningococcal septicaemia, IC, meningitis post surgery

prophlaxis for all household members = ciprofloxacin or rifampicin

follow up for bacterial meningitis = hearing test

prevention = vaccination against HiB, Men B & C

What are the S&S of raised ICP

symptoms
early morning headache
vomiting w/o nausea
altered consciousness

signs
Cushing’s triad
bradycardia
HTN w widening pulse P
irregular breathing — Cheyne-Stokes respirations
CN palsies
papilloedema

if child
tense/bulging fontanelle
setting sun sign
macrocephaly

what if blood in LP —– traumatic tap vs SAH
traumatic tap = 20% of LPs
r/o w “three tube test” — compare RBC in 1st & last tubes
sig less blood in 3rd than 1st = traumatic tap likely
also test for xanthochromia to r/o SAH

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10
Q

acute asthma attack —– approach + Tx

A

impression = acute asthma attack
DDx = pneumonia, pneumothorax, pulmonary oedema

resus ABCDEs

focused Hx

symptoms

features of life-threatening asthma attack
unable to speak
confused
cyanotic
poor respi effort
silent chest
SpO2 <92%
PaO2 <8 kPa
PEFR <33% predicted!!!
hypotension
bradyarrhythmia

any Hx of severe asthma attack —- since warrants admission even in absence of life-threatening features

Ix

bedside: ABG + lactate — ? respi failure
normal or raised PaCO2 = xfer to HDU/ICU
bloods: FBC, U&R, CRP, C&S
sputum C&S
PEFR

Tx

indications for hospital admission
life-threatening asthma attack
severe asthma + failure to respond to Tx
moderate asthma + pregnant or Hx of severe asthma attack

high dose (5mg) nebulised salbutamol (SABA)
repeat at 15 min intervals for 45 mins
if no improvement = repeat every 1-4 hrs
if no improvement = continuous nebuliser
if unresponsive = add ipratropium bromide 0.5mg (SAMA)

PO/IV systemic steroids —- PO prednisolone 40mg OD
if cant PO = IV hydrocortisone 100mg QDS + change to PO ASAP
duration: 5 days

consider escalating if not improving
xfer to ICU
NIV — BiPAP
IV MgSO4
IV aminophylline
IV salbutamol

other considerations
infectious cause = empirical Abx
hypoK sec to excessive salbutamol = IV fluids + KCl

criteria for discharge
stable on discharge meds (nebs or O2 discontinued) for 12-24 hrs
inhaler technique checked + recorded
emergency action plan written
PEFR >75% of best or predicted

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11
Q

suspected poisoning — approach + Tx

A

resus ABCDEs
check vitals + glucose + GCS
airway: head tilt + chin lift +/- oropharyngeal airway
if need be + expertise available = endotracheal intubation
breathing: supplementary O2 —- 4L via nasal prongs
if need = escalate to 15L via non-rebreather mask
if still cmi = call anaesthesia or ICU
circulation: insert 2 wide bore 14-16G IV Cannulas

call for senior help

focused Hx +/- collateral Hx
what did they take + when + how much
any symptoms/problems so far

physical exam
decreased LOC
opioid toxicity = pin point pupils + repsi depression –> arrest

CALL TOXBASE!!!

Ix
bloods
serum tox screen
paracetamol levels
LFTs
U&Es
+/- CT Brain —- if ? head injury

reduce absorption within 1 hr — by
activated charcoal
gastric lavage —- usually caustic/acidic contents
whole bowel irrigation — if lithium/iron

increased elimination by IV fluids +
if paracetamol at 4 hrs is over the Tx line on nomogram OR if <60 kg OR staggered OD = NAC N-acetylcysteine
if opioids OD + slowing of breathing or low GCS = naloxone 400 micrograms IM + repeat PRN
if BZD OD = flumazenil

psychiatric referral

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12
Q

attempted suicide or self harm — approach

A

what happened

details of event
method — if meds = what dose + where did you get them + do you still have any
where, when, alone
planned or impulsive
perceived lethality
precipitant? why then?
substance use
final acts
efforts to avoid discovery
actions after the act —- ie how did they end up in hospital
what did they think would happen

what led up to the episode?

risk assessment

current feelings — thoughts, plan, intent
prev attempts or self harm
stressors
psych Hx
screen for other mental illness — depression, EUPD, psychosis, substance use, postnatal depression
harm to others/dependents
screening for medical comorbidities

long term planning
refer to community mental health services
refer to voluntary counselling or support services
depending on severity
admit patient
arrange for follow up soon post-discharge

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13
Q

COPD exacerbation — approach + Tx

A

approach

impression = COPD exacerbation
DDx = pneumonia, pneumothorax, etc

resus ABCDs
supplementary O2 — 4L via nasal prongs or 10L via non-rebreather mask
titrate to SpO2 88-92% —- risk of respi depression if over-oxygenated
if not improving = BiPAP
2 wide bore 14-16G IV Cannulas + resus fluids

focused Hx

features of life-threatening acute respi failure
RR >24
use of accessory muscles
acute changes in mental state hypoxaemia not improving with supplemental O2
hypercarbnia or acidosis

Ix
bedside: ABG + lactate, ECG
bloods: FBC, U&E, C&S
sputum C&S
PEFR
CXR

monitoring
serial ABG — pH & PaCO2 normalise
SpO2

Tx of acute COPD exacerbation

nebulised SABA + SAMA — salbutamol 5mg + ipratropium bromide 0.5mg (combivent)

PO prednisolone 30mg for 5 days

if ?bacterial infection = empirical Abx acc to local hospital guidelines
1st line = amoxicillin/clarithromycin/doxycycline
if v.severe or failure to improve = co-amoxiclav

chest physiotherapy — expectorate sputum

others
monitor fluid balance
VTE prophylaxis

check if xfer to HDU/ICU required

criteria for discharge
S&S resolved
meds reviewed + optimised
inhaler technique assessed
exacerbation treated

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14
Q

on call: nurse calls you + patient has poor urinary output — approach + Tx of AKI

A

approach

impression = AKI or urinary retention or UTI

ask on the nurse
trend — sudden (eg. blockage) vs gradual (eg. hypovolaemia, UTI)
vitals

resus
circulation — if hypovolaemic = fluid bolus 250ml normal saline over 15 mins

call for senior help

focused hx

symptoms
trend – sudden vs gradual
fluid balance chart
+ve balance?
adequate intake?

DDx causes of AKI (will type below )

grade severity acc to KDIGO classification
mild = serum Cr 1.5-1.9x baseline or U/O <0.5ml/kg/hr for 6-12 hrs
moderate = serum Cr 2-2.9x baseline or U/O <0.5 ml/kg/hr for >12 hrs
severe = serum Cr >3.0x baseline or U/O <0.3 ml/kg/hr for >24 hrs or RRT required

physical exam
heart, abdo, renal
r/o urinary retention — ?palpable bladder, pulmonary oedema

Ix
bedside: VBG + electrolytes, ECG (since K+ abnormal), urine dipstick
bloods: FBC, U&E
BUN/Cr >20 = pre-renal; <15 = renal
urea x 10 > Cr = pre-renal
imaging: CXR, renal US

Tx of AKI

assess need for emergency dialysis — AEIOU
(impt coz takes a few hrs to prepare)
A: acidosis (pH <7.1)
E: electrolyte imbalance (K+ >7 or refractory hyperK + ECG changes)
I: intoxication (ethylene glycol, lithium)
O: overload (severe pulmonary oedema w oliguria or diuretic R)
U: uraemic complicatons (pericarditis or encephalopathy)

4 Ms

monitor: fluid balance, BP, U/O, K+, Cr, lactate
BP esp impt for pre-renal AKI

maintain euvolaemia
pre-renal = fluid challenge +/- maintenance fluids if needed
renal = stop fluids + Tx pulmonary oedema

minimise kidney injury — hold nephrotoxins where possible

manage acute illness

long term = prevention of AKI
adequate hydration
if vascular cause = target CVS risk factors
avoid nephrotoxins where possible
appropriate prescribing for age, weight & renal function

DDx causes of AKI

pre-renal
reduced perfusion – ie shock
cardiogenic
septic
hypovolaemic
neurogenic
anaphylactic
renal vasoconstriction
NSAIDs, ACEI/ARBs
renal A stenosis
hepatorenal syndrome

renal
ATN acute tubular necrosis
acute interstitial nephritis
glomerulonephritis
rhabdomyolysis
tumour lysis syndrome
drugs — Abx (gentamicin), contrast

post-renal
BPH
kidney stones
blocked/malsited catheter
malignancy
strictures – sec to trauma (cystoscopy)
voiding dysfunction — spina bifida, atonic bladder, cauda equina syndrome

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15
Q

on call: hypertension — approach + Tx

A

approach

impression = impt to r/o hypertensive urgency or emergency

ask the nurse
how high is the BP
any symptoms that suggest end-organ damage or complications — stroke, MI, visual disturbances, reduced urine output

resus ABCDEs

focused Hx

symptoms
new confusion
new blurred vision
new acute HF — SOB, oedema, etc
acute aortic dissection

DDx causes — esp reversible ones
missed antihypertensive meds
substance withdrawal — nicotine, alcohol, BZDs
pain
urinary retention
constipation
hypoxia

physical exam

Ix
bedside: fundoscopy, ECG
bloods: FBC, U&E, BNP
imaging: CT Brain, CXR

Tx

if BP <180/110 + no end organ damage
Tx any precipitants
no antihypertensives required acutely

guidelines if hypertensive urgency/emergency — ie BP >180/110
treat as long as no C/I — eg. ischaemic stroke
timeline
urgency = within a few hrs
emergency = immediately reduce
goal of therapy in emergency = reduce MAPby 25% in 1st 2-3 hrs
once stable = further reduce SBP to 160 mmHg
note: rapid reduction = risk of cerebral or myocardial ischaemia, AKI

if hypertensive urgency:
amlodipine 5mg PO STAT (if not alr on a CCB)
can repeat again if needed
+/- ACEI
+/- diuretic

if hypertensive emergency:
xfer to HDU or resus + consult senior
labetalol 10mg IV over 2 mins
can repeat every 10 mins if needed

special situations

acute ischaemic stroke
closely observe + dont treat as long as BP <220/120
if >220/120 = give labetalol

myocardial infarction
consult med reg — IV GTN
manage pain – can make BP increase

aortic dissection
reduce BP to 120 mmHg in 1st 20 mins
call surg reg immediately — needs labetalol

16
Q

haemoptysis — approach + Tx

A

approach

impression = haemoptysis

resus ABCDEs

focused Hx

symptoms
true haemoptysis vs others — haematemesis, epistaxis, bleeding gums
vol of bleeding + duration

DDx causes
infection — fever, cough, yellow-green sputum
PE — sudden onset pleuritic chest pain + SOB
calculate wells score
TB —- B symptoms + Hx of foreign travel
cancer —- B symptoms + unexplained weight loss
vasculitis — renal symptoms

physical exam
respi exam
CvS exam

Ix
bedside: ECG, urine dipstick, +/- ABG (if SpO2 reduced)
bloods: FBC, U&E, CRP, ESR, d-dimers
sputum C&S
imaging: CXR, CT pulmonary angiogram

Tx

if acute massive blood loss (>100ml over 24 hrs) = IR for artery embolisation

bronchoscopy

Tx cause

17
Q

DDx desating

A

pulmonary oedema
aspiration events
PE
COPD exacerbation

less common
TACO
pneumothorax
haemorrhage
CNS causes

18
Q

hyperK — approach + Tx

A

resus ABCDEs

focused Hx

symptoms
cardiac: arrhythmia, palpitations, chest pain, syncope
neuro: muscle cramps, hypotonia, paraesthesia, focal neuro signs, fatigue, weakness, depressed deep tendon reflexes

DDx causes

pseudohyperK: haemolysis
impaired excretion:
decreased glomerular filtration — AKI, CKD
hypoaldosteronism – adrenal insufficiency
increased intracellular K+ into ECF: cell lysis, reduced insulin (DKA)
increased K+ intake: large vol RBC transfusion, high dietary intake + impaired excretion

physical exam

Ix
ECG — check for cardiac membrane instability
tall tented t waves
small p waves
wide QRS complex
sine wave pattern, arrhythmias, asystole
VBG + electrolytes
bloods: FBC, U&Es

Tx

if K+ <6.5 + no ECG changes = calcium resonium 15g PO
Tx cause — eg. stop offending meds

if K+ >6.5 or ECG changes present = EMERGENCY!!

if ECG changes present = STABILISE CARDIAC MEMBRANE 1st! — calcium gluconate 10% 10ml over 10 mins slow IV injection
cardiac monitoring required
ideally large vein

drive K+ from ECF to ICF
insulin 10 units in 50ml of 50% dextrose over 10 mins
salbutamol 5mg nebulised

+/- calcium resonium 15g PO

if advanced renal disease = call renal team, if K+ reaching 7 = call ICU

long term
review meds — stop ACEI, ARBs, spironolactone, etc
avoid dietary K+

19
Q

hypoK — approach + Tx

A

resus ABCDEs

focused Hx

symptoms
neuro: lethargy, muscle weakness, paralysis, hypotonia, hyporeflexia
arrhythmia

DDx causes
intracellular-extracellular shifts
intensive insulin therapy – DKA
increased beta adrenergic activity — acute asthma, stress-induced
poor K+ intake
GI K+ loss
renal K+ wasting

physical exam
neuro exam
CVS — arrhythmias

Ix
ABG + electrolytes
ECG — findings: U waves, flattened/inverted T waves, ST depression, increased PR & QT
bloods: FBC, U&E (Mg too!)

Tx of hypoK

if mild = oral K+ supplements (Sandos K)

if severe — ie K+ <2.4 or dangerous symptoms
IV KCl slowly — 10 mmol/hr MAX
best via central line
DONT give boluses — cardioplegic!!

Mg replacement

20
Q

hyperCa — approach + Tx

A

resus ABCDEs

focused Hx

symptoms
bones — bone pain
stones — kidney stones
moans — psychic moans — AMS, confusion
groans – abdo groans — abdo pain, distension

DDx causes — VITAMINS TRAP
V: vitamin
I: immobility
T: thyrotoxicosis
A: AIDS
M: milk alkalais
I: inflammatory
N: neoplastic
S: sarcoidosis
T: thiazide diuretics
R: rhabdomyolysis
A: addison’s disease
P: paget’s disease of bone
pheochromocytoma
parathyroid
parenteral nutrition

kardex
thiazides
diuretics

physical exam

Ix
bedside: ECG, urine dipstick
bloods: FBC, U&E, PTH, Vit D, PTHrP
imaging: US kidneys, CT TAP, sestamibi scan, DEXA scan

Tx of hyperCa

rehydration: 0.9% normal saline
200-500 ml/hr — 3-4L per day — max 6L/day
monitor fluid volume status – if overload = furosemide

bisphosphonates — zolendronate IV
alternative = calcitonin mimetics — faster acting

acc to cause
cancer = steroids
CKD = dialysis

monitor Ca

21
Q

acute pancreatitis — approach + Tx

A

resus ABCDEs

focused Hx

symptoms
acute onset epigastric/LUQ pain
radiating to back
alleviated by sitting up + leaning forward
N&V

DDx of acute pancreatitis
abdominal:
perforated peptic ulcer
acute exacerbation of PUD
biliary colic
acute cholangitis
ischaemic bowel
ruptures/leaking AAA
abdominal aortic dissection
subdiaphragmatic:
basal pneumonia
ACS acute coronary syndrome

DDx causes of acute pancreatitis —- I GET SMASHED
I: idiopathic
I: iatrogenic
G: gallstones
E: ethanol
T: trauma
S: steroids
M: mumps
A: autoimmune
S: scorpion toxin
H: hypertriglyceridaemia
H: hypercalcaemia
E: ERCP
D: drugs

physical exam
?signs of peritonism — rebound tenderness, guarding, rigidity
?signs of haemorrhage
Grey-Turner sign = flank ecchymosis
Cullen’s sign = umbilical ecchymosis
Fox’s sign = inguinal ecchymosis

Ix
bedside: VBG + lactate
bloods: FBC, U&E, amylase, lipase, Ca(part of glasgow imrie), LFTs
imaging: erect CXR, PFA, +/- CT TAP

diagnostic criteria (Japan guidelines??)
typical Hx — acute onset + epigastric/LUQ pain
amylase or lipase >3x ULN
radiological findings consistent w pancreatitis

risk stratify the acute pancreatitis — acc to RANSON criteria or Glasgow Imrie

Tx of acute pancreatitis

fluid resus!!! — likely dehydrated due to 3rd spacing

NPO + maintenance fluids

insert urinary catheter — monitor U/O

analgeisa

Tx underlying aetiology

if ?concomitant infection = empirical Abx

22
Q

septic arthritis —– approach + Tx

A

approach

impression = septic arthritis
DDx incl cellulitis, gout, pseudogout, osteomyelitis

resus ABCDEs

focused Hx

symptoms

DDx causes

DDx risk factors for septic arthritis
age
immunosuppression
iatrogenic
co-morbidities — RA or DM
IVDU

physical exam
MSK: hot + red + swollen + tender joint
reduced ROM

Ix
bloods: FBC, U&E, C&S, CRP

joint aspiration:
purulent fluid = ?bacterial infection
WCC & differential — normal <180/mm3, infection = >75k/mm3
C&S
gram stain
light microscopy for crystals

xray of joint, AP + lateral views, + joint above & below

tx of septic arthritis:
empirical Abx acc to local hospital guidelines – flucloxacillin IV then PO 6 wks total
modify acc to C&S results

+/- joint irrigation & drainage

why not vancomycin in case its MRSA?
antimicrobial stewardship —> reduced resistance
unless there is reason to believe patient might have MRSA
eg. recent broadspectrum Abx use
recent hospital stay
immunocompromised

23
Q

thyrotoxicosis — approach + Tx

A

approach

impression = thyrotoxicosis

resus ABCDEs
vitals: tachycardia +/- afib

focused Hx

symptoms
flushing
anxiety
palpitations
acute abdomen
chest pain

DDx triggers
MI
surgery
radioiodine
stress
infection

physical exam
AMS: agitation, confusion, coma
signs of acute HF — raised JVP, peripheral oedema, etc
thyroid eye disease

Ix
bedside: ECG — r/o MI
bloods: TFTs, U&E, troponin, C&S
expected TFTs = undetectable TSH + high free T3 & T4
follow up Ix
radioactive iodine uptake
TRAbs (TSH receptor Ab) — ?Graves’ disease
doppler US for thyroid

Tx

acute Tx
symptom control = propranolol IV or digoxin
antithyroid = methimazole
4 hrs later = lugol’s iodine
reduce conversion of T4 to T3 = hydrocortisone 100mg IV QDS

definitive Tx

medical:
carbimazole (doubt thats enough tho)
radioactive iodine

surgical: total/subtotal thyroidectomy

24
Q

addisonian crisis —– approach + Tx

A

approach

DDx
hypoglycaemia
hypothyroidism
addisonian crisis
sepsis

resus ABCDEs
DEFG!!! — dont ever forget glucose

focused Hx

symptoms
collapse
tiredness
abdo pain
diarrhoea, vomiting
salt craving

DDx risk factors of addisonian crisis
exogenous glucocorticoid use
known addison’s disease or pituitary disease
disseminated TB
immune checkpoint inhibitors — ipilumumab
PPH — Sheehan’s syndrome
bilateral adrenalectomy

physical exam
tanned, hyperpigmented palmar creases
buccal mucosa

Ix
bedside: VBG + lactate (NAGMA), capillary blood glucose (hypoglycaemia)
bloods: FBC, U&E (low Na, high K), glucose, Ca, C&S
if secondary adrenal insufficiency = hypoNa + normal K

Tx addisonian crisis

hydrocortisone 100mg IV STAT
then 50mg IV STAT TDS
once stable = change to hydrocortisone PO (sick day dose – ie 2x normal dose)

IV fluids — 0.9% NaCl +/- 5% dextrose
(coz hypoaldosteronism — so low Na)
address hypoNa + hypovolaemia

Tx hypoglycaemia

Tx any trigger — eg. infection

follow up

short synacthen test — only do once well
Ix for cause of adrenal insufficiency —- eg. 21 hydroxylase Ab

transition to standard replacement
10mg hydrocortisone mane (morning) + 5mg at lunch
if primary adrenal insufficiency (ie Addison’s disease) = fludrocortisone
once hydrocortisone <50mg/day

25
Q

DKA — approach + Tx

A

approach

impression = DKA

resus ABCDEs
DEFG! dont ever forget glucose

focused Hx

symptoms
glycosuria — polydipsia, polyuria, weight loss, lethargy
N&V
abdo pain
muscle cramps

DDx precipitants
infection (30-40%)
Tx non-compliance (20-30%)
MI

physical exam — if severe
tachypnoea — ketotic breath, kussmaul’s breathing
neuro: reduced GCS, confusion, coma, seizures
vol deplete
decreased skin turgor
dry mucous membranes
prolonged cap refill
reduced U/O

Ix

bedside
capillary blood glucose
ECG
urine dipstick
VBG + lactate

bloods: FBC, U&EE
insulin levels, serum glucose, serum ketones, serum osmolality

diagnostic criteria of DKA
blood glucose >11.1 mmol/L
serum ketones >3
acidosis — pH <7.3 or bicarb <18

Tx

move patient to resus/HDU/ICU
monitor cardiorespi status
fluid & electrolyte balance

fluid resuscitation
if SBP <90 = 500ml bolus NS STAT over 10-15 mins
if SBP >100 = 1L NS STAT then 1L each over 2,4,6,8 hrs

check K+ levels
if K<3.3 = give 40 mmol KCl over 1L NS
if K 3.3-5.3 = give 20 mmol KCl over 1L NS
if K>5.3 = dont need additional KCl, just monitor K levels

once blood glucose <14 mmol/L = add 200ml/hr of 5% dextrose

insulin (actrapid) – FRII 0.1 unit/kg/hr
once blood glucose 10-14 mmol/L = change to VRII

VTE prophylaxis — LMWH + TED stocking

monitor
U&R, serum glucose, serum ketones, VBG
neuro obs — GCS
telemetry – ?hypokalaemia arrhythmias

Tx underlying cause

26
Q

HHS Hyperglycaemic hyperosmolar state — approach + Tx

A

approach

impression = HHS

resus ABCDEs
DEFG! dont ever forget glucose!

focused Hx

symptoms:
glycosuria — polydipsia, polyuria, weight loss, lethargy
N&V
abdo pain
muscle cramps

DDx cause

physical exam
profound hypovolaemia
vitals — tachycardia, reduced BP
decreased skin turgor
dry mucous membranes
prolonged cap refill time
reduced U/O
postural hypotension
AMS — coma, confusion

Ix

bedside:
capillary blood glucose
VBG + lactate
urine dipstick – ketonuria

bloods: FBC, U&E
insulin levels, serum glucose, serum ketones, serum osmolality

diagnostic criteria of HHS:
serum glucose >30 mmol/L
serum osmolality >350 mOsm
normal: 270-275 mOsm
no/minimal ketonaemia
no acidosis

Tx

fluid resus
if SBP <90 = NS 1L/hr fo 3-4 hrs
if SBP >100 = fluids acc to corrected Na
corrected Na = Na + (glucose/2.3)
if cNa >135 = hypotonic saline (0.45% NaCl) 250-500 ml/hr
if cNa <135 = isotonic saline (0.9% NaCl) 250-500ml/hr

check K+ and add accordingly
if K+ <3.3 = hold insulin + give 20 mmol KCl per hr until K+ >3.3
requires cardiac monitoring
if 3.3 < K+ < 5.3 = add 20 mmol KCl per 1L of IV fluids
if K>5.3 = monitor K+, no supplementation required

once blood glucose <14 mmol/L = add 125 ml 5% dextrose per hr

if rehydration insufficient = insulin
FRII 0.05 units/kg/hr

Tx DKA vs HHS —- HHS Tx
fluid resus more rapid
if cNa >135 = hypotonic saline
gentler insulin regime — to avoid cerebral oedema
aggressive use of IV Abx — prevent UTI or URTI development afterwards `

27
Q

hypoglycaemia — approach + Tx

A

approach

impression
hypoglycaemia
hypothyroidism
addisonian crisis
sepsis

resus ABCDEs
DEFG — dont ever forget glucose

focused Hx

symptoms

DDx causes of hypoglycaemic event
excess insulin or oral hypoglycaemics
alcohol
critical illness
hormone deficiency — eg. low cortisol
endogenous cause of high insulin — eg. insulinoma
post gastric bypss hypoglycaemia

physical exam
vitals — increased HR, BP
diaphoresis
pallor
confusion

diagnosis of symptomatic hypoglycaemia = whipple’s triad
symptoms consistent w hypoglycaemia
measured low plasma glucose (<2.2 mmol/L)
relief of symptoms after plasma glucose has been raised

Tx of hypoglycaemi

if conscious
15-20g fast acting carbohydrates — eg. glucotabs, lucozade, sweetened juice
long-acting carbohydrates —- eg. slice of toast, porridge
prevent recurrence

if unconscious = EMERGENCY
if outside hospital = glucagon 1mg IM
if in hospital = 100ml 20% dextrose
caution: phlebitis
if prolonged hypoglycaemia = consider dextrose infusion
once conscious = same as above

complications

acute phase:
seizures
aspiration
neuro complications
coma — death

hypoglycaemic unawareness = hypoglycaemia occuring w/o warning symptoms
high risk of coma
more likely to occur if frequent hypos + long duration of DM
prevention: higher glycaemic goals + avoid hypos until awareness improves

28
Q

hypoNa — approach + Tx

A

approach

resus ABCDEs

if symptomatic = call MROC — emergency!!!

focused Hx

symptoms
(least serious)
asymptomatic
N&V, confusion, headache
seizure, pulmonary oedema
coma, stroke, osmotic demyelination syndrome
cognitive dysfunction, falls, osteoporosis
(most serious)

time frame of symptoms – acute vs chronic

DDx causes + precipitants

physical exam
volume status — hypo vs euvo vs hypervolaemia
I/O

Ix
bedside: VBG + electrolytes
bloods: FBC, U&E
urine osmolality + urine Na?

work out serum osmolality = 2Na + K + glucose + urea
check if true hyponatraemia — reduced serum osmolality = true hypoNa

tx

acute hypoNa:

If severe = 100ml hypertonic saline (3% NaCl) over 10 mins
repeat up to 3x
monitor Na hrly

if mild-moderate = 0.5-2ml/krhr hypertonic saline

if mild + asymptomatic = no hypertonic saline required

correction limited to 8-10 mmol/L in 24 hrs

chronic hypoNa:

max 8 mmol/L per day increase in Na —- to prevent osmotic demyelination syndrome

if hypervolaemic hypoNa:
fluid restrict
vasopressin receptor antagonist (ie ADH antagonist) —- tolvaptan
+/- loop diuretics
Tx underlying disorder

if euvolaemic hypona:
fluid restrict
Tx underlying cause
+/- vasopressin antagonist —- if fluid restriction insufficient

if hypovolaemic hypoNa
fluid replacement w isotonic saline
if symptomatic = aim 3-6 mmol/L per day increase

always monitor Na levels

complications

rapid correction = osmotic demyelination syndrome
irreversible!! — permanent neuro deficits

acute: seizures, coma —> death
chronic: falls, osteoporosis —> fractures

29
Q

hyperNa — approach + Tx

A

resuscitation

approach

focused Hx

symptoms:
thirst
confusion
muscle weakness
if severe = stupor, coma, seizures

DDx causes
delirium or CI
hospitalised + inadequate free water
impaired thirst mechanism

kardex:
meds — esp IV saline, Abx

physical exam
signs of hypovolaemia
check U/O
hyperreflexia, spasticity

Ix
bloods: FBC, U&E
monitor U/O

Tx
address cause

fluid replacement
ideally = oral rehydration salts
if cant = IV fluids
if euvolaemic = 5% dextrose 1L over 6 hrs
if hypovolaemic or unstable = normal saline (at a faster rate)
hypercoagulable state

follow up
check plasma + urine osmolality
desmopressin administration
indication: urine < plasma osmolality
central cause = urine becomes concentrated
nephrogenic = urine becomes dilute

30
Q

hypocalcaemia — approach + Tx

A

VIVA
* Approach
○ Resus ABCDEs
§ Can cause spasms of the larynx –> obstruct airway –> may require airway support
○ Focused Hx
§ Symptoms — SPASMODIC
□ S: spasms — carpopedal = trousseau
□ P: perioral paraesthesia
□ A: anxious/irritable
□ S: seizures
□ M: muscle tone increase — colic, wheeze, dysphagia
□ O: orientated/confused
□ D: dermatitis
□ I: impetigo herpetiformis
□ C: chvosteck’s or cardiomyopathy
§ DDx causes
□ Overt calcium loss
® Acute pancreatitis
® Cell lysis
® Extensive transfusion
® Osteoblastic mets — prostate or breast ca
□ High PTH
® CKD
® Vit D deciency
® Drugs – bisphosphonates, denosumab
□ Low PTH
® Hypoparathyroidism
® hypoMg
○ Physical exam
○ Ix
§ ECG — long QT — torsades de pointes
§ Bone profile
§ Vit D
* Tx
○ Ca + Vit D supplements (calcichew D3 forte) +/- active vit D
○ If severe = slow push 10% calcium gluconate 10ml over 10 mins
§ Then 10 vials of 10% calcium gluconate in 1L normal saline over 10 hrs
○ Mg replacement

Surgical intern for ENT: 44 y/o lady who had thyroidectomy due to thyrotoxicosis yesterday + Hx of epilepsy —- O/E: febrile + started to twitch
* Impression
○ Post-op fever
○ Transient hypocalcaemia post-op
○ Hungry bone syndrome
○ Epilepsy seizure
* If you see increased swelling + exudate — what would you do
○ Surgical emergency!!! — could die in an hr w/o intervention due to airway obstruction
○ Call for help
○ Open the wound
§ Remove steristrips
§ Cut subcuticular sutures
§ Open skin & strap muscles
§ Evacuate haematoma with fingers
§ Cover wound
○ Surgery to secure bleeding
* And if its not a wound issue how would u proceed?
○ If hypocalcaemia?
○ If hypoNa + seizing?