Vitamin D Flashcards
What is the sources of the vitamin D
Liver kidney slamon fish
Milk diary productes
What does the UV light do to the vitamin D formation
It convert 7-dehydrocholesterol
To cholecalciferol
What happens to the cholecalciferol
It entera the liver and turned into 25 hydroxycholcalciferol
What are the cofactors for the 25 hydeoxylase enzyme
Mg
NADPH
O2
What happens ro the 25hydroxycholclaciferol in the kindeny
He kidney will have enzyme called 1-alpha hydroxy that is induced by the parathyroid hormone to convert it to 1,25DHCC
What does the 1-alpha hydroxy need as a cofactors
Mg
NADPH
O2
Which enzymes does the 1-alpha hydroxy need ?
Ferrodoxin reductase
Ferrdoxin
Cytochrome P450
What happens to the extra 1,25DHCC
It ia converted to inactive forms
How does the PTH increase the Ca level in the serum
1-absorption of ca from intestine
2-reabsorption ca in the kidney (DCT)
3-resorption of bones
What is the effect if the PTH on the phosphate
It lost it in the PCT
What is the difference between the PTH calcitonin and vit D on Ca and phosphote level
PTH increase ca decreases phosphate
Calcitonin decrease both
Vit D increase both
Whqt is he name of the receptors that vit D effect
Zinc finger
What mineral deficiency cause vit D deficiency
It is Mg
What is the feeding milk lack to
FeDK
Why the children have a high alkaline phosphatase than normal
Because they are growing
