Glycolysis Flashcards
What is the mnemonic for the GLUT
BBB
blood RBCs
Blood brain barrier I
Baby fetus
Kids LiPs
Kidney
Liver. II
Pancreas
PiNK
Placenta
Neurons. III
Kidney
Mother
Muscles. IV. Insulin dependent
Father
Fat adipose
Where does the glycolysis happens
In the cytoplasm
If we have high
LDH (lactate dehydrogenase )
In the blood
It means that a lot of pyruvate is converting into lactic acid
And we have a blood in get oxygen to some cells that why they are use anaerobic energy process
What are the name of the enzymes that convert glucose to glucose-6-phosphate
Hexokinase
Glucokinass
What are the alloseteric regulators of the hexokinase
Increased glucose stimuli
Interested glucose-6- phosphate inhibit
What regulates glukinase
Tw hormone
Insulin stimuli
Glucagon inhibit
What are the allosteric regulators of the phosphate fractose kinase1
Stimuli:
F2,6BP
increased ADP
inhibit:
Increased ATP
increased citrate
How does the insulin stimuli
PFK1
By stimuli of FPK2 that convert A F6P
To F2,6BP which is the most powerful stimuli
Is the glycolysis anaerobic or aerobic
It is anaerobic
What is the final product of glycolysis
It is 2 pyruvate
What is the ATP use and production in glycolysis
We use 2 ATP we produce 4 ATP
with 2 ATP net
What si the main stimuli to pyruvate kinase
It is f1,6bp
How does the insulin and glucagon control the enzymes action
Insulin by dephosphorylation
glucagon by phosphorylation
What are the controlling levels of the anabolic and catabolic pathways
1- allosteric that inhibits or activate of rate-limiting enzymes
2- insulin and glucagon effect
3- control of the gens that produce insulin and glucagon
Which tissues are insensitive to insulin
Brain and RBCs
What is the most important enzyme in the glycolysis for the RBCs
It is the pyruvate kinase because the RBCs do not have a mitochondria so they cannot do the ETC so the only source of Energy is the 2ATP which are the net gain from the glycolysis
What us the ATP source of the RBCs although they don’t have mitochondria
They get 2 ATP. From glycolysis
And they use the anaerobic pathway to get ATP from pyruvate
