Vitamin B1 Flashcards
1
Q
Aka
A
Thiamine
2
Q
Coenzyme
A
Thiamine pyrophosphate TPP
3
Q
Sulphur containing vitamins
A
Thiamine and biotin
4
Q
Chemistry
A
Has a pyramidine ring and thiazole ring linked by methylene group
5
Q
Biochemical functions
A
- pyruvate dehydrogenase
- alfa ketoglutarate dehydrogenase
- transketolase of HMP shunt
- transmission of nerve impulse
6
Q
Daily requirement
A
1-1.5 mg per day
7
Q
Manifestations
A
Wet beri beri
Dry beri beri
Infantile beri beri
8
Q
Wernicke korsakoff syndrome
A
In alcoholics requirement of thiamine is increases
Inadequate intake and impaired intestinal absorption leads to cns manifestations
Nystagmus ophthalmoplegia, cerebral ataxia— wernickes encephalopathy
When there is mental impairment resulting in loss of memory and apathy—Korasakoffs psychosis
