Folate

Question 1

Folic acid active form

Answer 1

Tetrahydrofolate

Question 2

Functions of folate in AA metabolism

Answer 2

Conversion of serine to glycine
Catabolism of histamine
Synthesis of methionine

Question 3

Functions of folic acid

Answer 3

Role in DNA AND RNA synthesis
-one C groups r used for the synthesis of C2 and C8 of purine ring
Also help in the formation of tmp(thymidylate)

Role in Aa synthesis

Role in protein synthesis

Question 4

Daily requirement

Answer 4

200 mew/day

400 pregnancy
300 lactation

Question 5

Deficiency manifestation

Answer 5

• neural tube defects : spina bifida,anencephaly, encephalocele
• hyperhomocysteinemia: CAD
• macrocytic anaemia with megaloblastic changes in bone marrow

Question 6

Folate antagonists

Answer 6

• aminopterin n amethopterin: inhibit dihydrofolate reductase.used widely as anti cancer drugs
• trimethoprim n sulphonamides : inhibit folate reductase. Used as bactericidal drugs