Vit E Flashcards
Types
4 tocopherols- sat. side chains
4 tocotrienols- unsat. side chains
Food sources
Plants, leaves and other greens, soybeans, animals -Vit E, fatty animal tissue
Digestion
requires estrases, bile salts
20-50% absorption
stored in adipose tissue, liver muscles, lung, heart, adrenal gland and brain
Functions
antioxidant- protects cell membrane, from ox of UFA
-prevent LDL ox
maintain nervous /immune system
protect PUFA (surrounds cell to protect membrane)
Diseases
type II diabetes-improves metabolic control
cataracts- formed by protein ox in lens of eye
iron toxicity- production against iron -induced cell damage
heart disease- increases of vit E may reduced HD
- reduced ox of LDL
- more than 7 mg/d of V-E
RDA
15 mg/day
UL= 1,000 mg/d
Deficiency
Symptoms:
Hemolytic anemia, muscle weakness, degenerative effect, neurological problems
uncommon- except w/certain disorders
-fat malabsortion -cystic fibrosis
- cholestasis- decreased production of bile
Toxicity
100x RDA= chronically no harm hemophiliac should avoid supplements
Assessment
-erythrocyte malondialaldyhe test- + h2o2 to RBC
RBC hemolysis test-most convient- less than 20% deficiency.
Serum levels= not accurate